1-BOC-3-(METHOXY)AZETIDINE

Base Information

• Chemical Name: 1-BOC-3-(METHOXY)AZETIDINE
• CAS No.: 429669-07-8
• Molecular Formula: C9H17 N O3
• Molecular Weight: 187.23618
• Hs Code.: 2933990090
• Mol file: 429669-07-8.mol

Synonyms:tert-Butyl 3-methoxyazetidine-1-carboxylate

Chemical Property of 1-BOC-3-(METHOXY)AZETIDINE

Chemical Property:

• Boiling Point: 232.8±33.0 °C(Predicted)
• PKA: -2.86±0.40(Predicted)
• PSA: 38.77000
• Density: 1.06±0.1 g/cm3(Predicted)
• LogP: 1.19000
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-3-methoxyazetidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-BOC-3-(METHOXY)AZETIDINE

There total 5 articles about 1-BOC-3-(METHOXY)AZETIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 3-hydroxyazetidine-1-carboxylate (141699-55-0) + methyl iodide (74-88-4) → tert-butyl 3-methoxyazetidine-1-carboxylate (429669-07-8)

Guidance literature:

tert-butyl 3-hydroxyazetidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; for 2h; Inert atmosphere;

DOI:10.1021/ol403626k

Reference yield: 98.0%

tert-butyl 3-oxoazetidine-1-carboxylate (398489-26-4) + methyl iodide (74-88-4) → tert-butyl 3-methoxyazetidine-1-carboxylate (429669-07-8)

Guidance literature:

tert-butyl 3-oxoazetidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02848

Reference yield: 58.0%

→ tert-butyl 3-methoxyazetidine-1-carboxylate (429669-07-8)

Guidance literature:

upstream raw materials:

methyl iodide

tert-butyl 3-hydroxyazetidine-1-carboxylate

di-tert-butyl dicarbonate

tert-butyl 3-oxoazetidine-1-carboxylate