5'-O,3'-O,2'-O-tris(tert-butyldimethylethylsilyl)-6-O-benzyl-2-bromoguanosine

Base Information

Chemical Name:5'-O,3'-O,2'-O-tris(tert-butyldimethylethylsilyl)-6-O-benzyl-2-bromoguanosine
CAS No.:845254-25-3
Molecular Formula:C₃₅H₅₉BrN₄O₅Si₃
Molecular Weight:780.038
Hs Code.:

Synonyms:5'-O,3'-O,2'-O-tris(tert-butyldimethylethylsilyl)-6-O-benzyl-2-bromoguanosine

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Chemical Property of 5'-O,3'-O,2'-O-tris(tert-butyldimethylethylsilyl)-6-O-benzyl-2-bromoguanosine

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Technology Process of 5'-O,3'-O,2'-O-tris(tert-butyldimethylethylsilyl)-6-O-benzyl-2-bromoguanosine

There total 4 articles about 5'-O,3'-O,2'-O-tris(tert-butyldimethylethylsilyl)-6-O-benzyl-2-bromoguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.7%

: 253779-52-1
5'-O,3'-O,2'-O-tris(tert-butyldimethylethylsilyl)-6-O-benzylguanosine

: 845254-25-3
5'-O,3'-O,2'-O-tris(tert-butyldimethylethylsilyl)-6-O-benzyl-2-bromoguanosine

Guidance literature:: With 2-Methyl-2-nitropropane; antimony(III) bromide; 1,2-dibromomethane; In toluene; at -10 ℃; for 1h;
DOI:10.1021/ja045108j

Reference yield:

: 72409-24-6
2',3',5'-tri-O-(tert-butyldimethylsilyl)guanosine

: 845254-25-3
5'-O,3'-O,2'-O-tris(tert-butyldimethylethylsilyl)-6-O-benzyl-2-bromoguanosine

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / diethylazodicarboxylate; Ph₃P / dioxane / 2 h

2: 61.7 percent / SbBr₃; t-BuNO₂; CH₂Br₂ / toluene / 1 h / -10 °C

With 2-Methyl-2-nitropropane; antimony(III) bromide; triphenylphosphine; diethylazodicarboxylate; 1,2-dibromomethane; In 1,4-dioxane; toluene;
DOI:10.1021/ja045108j

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 845254-25-3
5'-O,3'-O,2'-O-tris(tert-butyldimethylethylsilyl)-6-O-benzyl-2-bromoguanosine

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / imidazole / dimethylformamide

2: 64 percent / diethylazodicarboxylate; Ph₃P / dioxane / 2 h

3: 61.7 percent / SbBr₃; t-BuNO₂; CH₂Br₂ / toluene / 1 h / -10 °C

With 1H-imidazole; 2-Methyl-2-nitropropane; antimony(III) bromide; triphenylphosphine; diethylazodicarboxylate; 1,1-dibromomethane; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja045108j