(S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)dodec-11-ynoate

Base Information

Chemical Name:(S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)dodec-11-ynoate
CAS No.:1351669-55-0
Molecular Formula:C₄₈H₆₁NO₇S
Molecular Weight:796.081
Hs Code.:

Synonyms:(S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)dodec-11-ynoate

Suppliers and Price of (S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)dodec-11-ynoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)dodec-11-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)dodec-11-ynoate

There total 6 articles about (S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)dodec-11-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: (1S,2R)-2-(N-benzyl-N-(mesitylsulfonyl)amino)-1-phenyl-1-propyl dodec-11ynoate

: 61871-67-8
3-(3,4-Dimethoxyphenyl)propanal

: 1351669-55-0
(S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)dodec-11-ynoate

Guidance literature:: (1S,2R)-2-(N-benzyl-N-(mesitylsulfonyl)amino)-1-phenyl-1-propyl dodec-11ynoate; With triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In hexane; dichloromethane; at -78 ℃; for 2h;

3-(3,4-Dimethoxyphenyl)propanal; In hexane; dichloromethane; at -78 - 20 ℃; for 4h;
DOI:10.1002/anie.201102967

Reference yield:

: 7766-50-9
1-undecen-11-ylbromide

: 1351669-55-0
(S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)dodec-11-ynoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium / diethyl ether / 5 h / Reflux

1.2: 2 h / -40 °C

2.1: bromine / diethyl ether / 2 h / -5 °C

3.1: sodium amide / tetrahydrofuran; ammonia / 5 h / -45 - -35 °C / liquid NH₃

4.1: thionyl chloride / benzene / 3 h / Reflux

5.1: pyridine / dichloromethane / 15 h / 0 - 20 °C

6.1: triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane / hexane; dichloromethane / 2 h / -78 °C

6.2: 4 h / -78 - 20 °C

With pyridine; thionyl chloride; bromine; sodium amide; magnesium; triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; ammonia; benzene; 6.1: Aldol condensation / 6.2: Aldol condensation;
DOI:10.1002/anie.201102967

Reference yield:

: 65423-25-8
11-dodecenoic acid

: 1351669-55-0
(S)-((1S,2R)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 2-((S)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl)dodec-11-ynoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / diethyl ether / 2 h / -5 °C

2.1: sodium amide / tetrahydrofuran; ammonia / 5 h / -45 - -35 °C / liquid NH₃

3.1: thionyl chloride / benzene / 3 h / Reflux

4.1: pyridine / dichloromethane / 15 h / 0 - 20 °C

5.1: triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane / hexane; dichloromethane / 2 h / -78 °C

5.2: 4 h / -78 - 20 °C

With pyridine; thionyl chloride; bromine; sodium amide; triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; ammonia; benzene; 5.1: Aldol condensation / 5.2: Aldol condensation;
DOI:10.1002/anie.201102967