61871-67-8

Basic information

• Product Name: 3-(3,4-DIMETHOXY-PHENYL)-PROPIONALDEHYDE
• Synonyms: 3-(3,4-DIMETHOXY-PHENYL)-PROPIONALDEHYDE;Benzenepropanal, 3,4-diMethoxy-
• CAS NO: 61871-67-8
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.22706
• Mol File: 61871-67-8.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 283.622°C at 760 mmHg
• Flash Point: 116.087°C
• Appearance: /
• Density: 1.055g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: 3-(3,4-DIMETHOXY-PHENYL)-PROPIONALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-DIMETHOXY-PHENYL)-PROPIONALDEHYDE(61871-67-8)
• EPA Substance Registry System: 3-(3,4-DIMETHOXY-PHENYL)-PROPIONALDEHYDE(61871-67-8)

Safety Data

• Hazardous Substances Data: 61871-67-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H14O3/c1-13-10-6-5-9(4-3-7-12)8-11(10)14-2/h5-8H,3-4H2,1-2H3

Upstream product

• 6258-35-1 3-(3,4-dimethoxyphenyl)prop-2-yn-1-ol 
• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 
• 5460-32-2 1-iodo-3,4-dimethoxybenzene 
• 107-18-6 allyl alcohol 
• 100157-47-9 3-(3,4-dimethoxyphenyl)-1,1-ethylendioxypropane 
• 4497-40-9 3,4-dimethoxy-cinnamaldehyde 
• 93-16-3 Methylisoeugenol 
• 5462-13-5 ethyl 3-(3,4-dimethoxyphenyl)propionate 
• 20583-78-2 3,4-dimethoxy-cinnamic acid ethyl ester 
• 27798-73-8 methyl 3-(3,4-dimethoxyphenyl)propionate 
• 14737-89-4 3,4-dimethoxy-trans-cinnamic acid 
• 2316-26-9 3,4-dimethoxycinnamic acid 
• 6380-23-0 3,4-dimethoxystyrene 
• 201230-82-2 carbon monoxide 

Downstream Products

• 87543-06-4 1-<4,4-(1,2-Benzenediyldithio)but-3-enyl>-4-dimethoxybenzene 
• 78376-20-2 5-[3-(3,4-Dimethoxy-phenyl)-1-hydroxy-propyl]-4-methoxy-5H-furan-2-one 
• 3929-47-3 3-(3,4-dimethoxyphenyl)-1-propanol 
• 100157-36-6 3-(3,4-dimethoxy-phenyl)-propionaldehyde-oxime 
• 184357-91-3 5-(3,4-dimethoxyphenyl)-4-formylpentanenitrile 
• 710313-47-6 (Z)-1-(3,4-dimethoxy)phenyl-6-isobutyl-8-methylnon-6-en-4-yn-3-ol 
• 160360-59-8 (R)-5-(3,4-Dimethoxy-phenyl)-pent-1-yn-3-ol 
• 1147862-92-7 N,N-diisopropyl-3-(3,4-dimethoxyphenyl)propan-1-amine 
• 1338700-00-7 (4R,4aR,9bS)-ethyl 7,8-dimethoxy-2-phenyl-1-tosyl-4,4a,5,9b-tetrahydro-1H-indeno[1,2-b]pyridine-4-carboxylate 

Relevant articles and documents

In silico design and synthesis of N-arylalkanyl 2-naphthamides as a new class of non-purine xanthine oxidase inhibitors

A series of N-arylalkanyl 2-naphthamides (Xa~e), which were predicted from virtual molecular docking on a built xanthine oxidase template as potential inhibitors, were synthesized. Their inhibitory activity against xanthine oxidase was assayed. Among these prepared, compounds Xb (IC50 13.6?μM), Xc (IC50 13.1?μM), and Xd (IC50 12.5?μM) showed comparable inhibitory activity to allopurinol (IC50 22.1?μM). The in vitro assay result correlated well with molecular docking scores, ΔG?=??16.99, ?17.66, and ?17.13 Kcal/mol, respectively. On the potassium oxonate-induced hyperuricemic mice model, oral administration of Xc-Ac (40 mg/ Kg), the per-O-acetylated Xc, could reduce the blood uric acid level by 60% in comparison to the normal control group and is statistically significant (p .01) while compared with the hyperuricemic mice group.

Synthesis of rac-ɑ-aryl propionaldehydes via branched-selective hydroformylation of terminal arylalkenes using water-soluble Rh-PNP catalyst

This work detailed the preparation of a class of water-soluble PNP ligands that differed by the nature of the substitute on phenyl ring of ligands. These ligands were incorporated into water-soluble rhodium-PNP complex catalysts that were used to regioselective hydroformylation of a series of terminal arylalkenes, providing efficient access to rac-α-aryl propionaldehydes in good to excellent yield (up to 97%) and branched-regioselectivity (up to 40:1 b/l ratio). Furthermore, gram-scale and diverse synthetic transformation demonstrated synthetic application of this methodology for non-steroidal antiinflammatory drugs.

BIOISPIRED PROTEASOME ACTIVATORS WITH ANTIAGEING ACTIVITY

The present invention relates to novel bio-inspired hybrid compounds of formula I which act as proteasome activators and exhibit anti-ageing activity, as well as methods for their synthesis. These hybrid compounds combine the structural features of hydroxytyrosol and the natural antioxidant vitamin E or its bioisosteres in one molecular scaffold. The compounds of formula I, which include structural proteasome activators (activation by stereochemical interaction), can be used in the production of anti-ageing products, such as cosmetic preparations. Additionally, they can be used in conditions and diseases where the proteasome is down-regulated, as well as proteasome-activation control compounds.