(1'R,4'S)-2-Amino-6-chloro-9-[4'-(tripenylmethoxymethyl)cyclopent-2'-en-1'-yl]purine

Base Information

Chemical Name:(1'R,4'S)-2-Amino-6-chloro-9-[4'-(tripenylmethoxymethyl)cyclopent-2'-en-1'-yl]purine
CAS No.:148555-12-8
Molecular Formula:C₃₀H₂₆ClN₅O
Molecular Weight:508.022
Hs Code.:

Synonyms:(1'R,4'S)-2-Amino-6-chloro-9-[4'-(tripenylmethoxymethyl)cyclopent-2'-en-1'-yl]purine

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Chemical Property of (1'R,4'S)-2-Amino-6-chloro-9-[4'-(tripenylmethoxymethyl)cyclopent-2'-en-1'-yl]purine

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Technology Process of (1'R,4'S)-2-Amino-6-chloro-9-[4'-(tripenylmethoxymethyl)cyclopent-2'-en-1'-yl]purine

There total 8 articles about (1'R,4'S)-2-Amino-6-chloro-9-[4'-(tripenylmethoxymethyl)cyclopent-2'-en-1'-yl]purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 148473-13-6
(1R,5R)-1-Acetoxy-5-(triphenylmethoxymethyl)cyclopent-2-ene

: 10310-21-1
2-Amino-6-chloropurin

: 148555-12-8
(1'R,4'S)-2-Amino-6-chloro-9-[4'-(tripenylmethoxymethyl)cyclopent-2'-en-1'-yl]purine

Guidance literature:: 2-Amino-6-chloropurin; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

(1R,5R)-1-Acetoxy-5-(triphenylmethoxymethyl)cyclopent-2-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; in the dark;
DOI:10.1039/a906464h

Reference yield:

: 148555-11-7
(1R,5R)-5-(Triphenylmethoxymethyl)cyclopent-2-en-1-ol

: 148555-12-8
(1'R,4'S)-2-Amino-6-chloro-9-[4'-(tripenylmethoxymethyl)cyclopent-2'-en-1'-yl]purine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / pyridine / 17 h / 20 °C

2.1: NaH / dimethylformamide / 20 °C

2.2: 55 percent / Pd(PPh₃)4 / dimethylformamide / in the dark

With pyridine; sodium hydride; In N,N-dimethyl-formamide; 1.1: Acetylation / 2.1: Metallation / 2.2: Addition;
DOI:10.1039/a906464h

Reference yield:

: 542-92-7,25568-84-7,7313-32-8
cyclopenta-1,3-diene

: 148555-12-8
(1'R,4'S)-2-Amino-6-chloro-9-[4'-(tripenylmethoxymethyl)cyclopent-2'-en-1'-yl]purine

Guidance literature:: Multi-step reaction with 7 steps

1: H₂O / 96 h / 0 deg C to r.t.

2: LiAlH₄ / tetrahydrofuran

3: NaIO₄ / diethyl ether; H₂O

4: NaBH₄ / methanol

5: Et₃N, Me₂NC₅H₄N / CH₂Cl₂

6: pyridine

7: NaH / (Ph₃P)4Pd / dimethylformamide; tetrahydrofuran

With pyridine; sodium tetrahydroborate; sodium periodate; lithium aluminium tetrahydride; Me₂NC₅H₄N; sodium hydride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/P19930000313