Technology Process of 7-(phenylthio)-2,3,3a,4,5,6-hexahydro-1H-isoindol-1-one
There total 5 articles about 7-(phenylthio)-2,3,3a,4,5,6-hexahydro-1H-isoindol-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
toluene;
for 1.5h;
Reflux;
DOI:10.1016/j.tet.2011.11.060
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate / toluene / 18 h / Inert atmosphere; Reflux
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethyl acetate / 24 h / 20 °C
3: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 1.5 h / Reflux
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
ethyl acetate; toluene;
1: intramolecular Diels-Alder reaction;
DOI:10.1016/j.tet.2011.11.060
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
2: sodium hydrogencarbonate / toluene / 18 h / Inert atmosphere; Reflux
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethyl acetate / 24 h / 20 °C
4: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 1.5 h / Reflux
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
ethyl acetate; N,N-dimethyl-formamide; toluene;
2: intramolecular Diels-Alder reaction;
DOI:10.1016/j.tet.2011.11.060
