Technology Process of 7-(phenylthio)-2-tosyl-2,3,3a,4,5,6-hexahydro-1H-isoindol-1-one
There total 3 articles about 7-(phenylthio)-2-tosyl-2,3,3a,4,5,6-hexahydro-1H-isoindol-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
ethyl acetate;
at 20 ℃;
for 24h;
DOI:10.1016/j.tet.2011.11.060
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
2: sodium hydrogencarbonate / toluene / 18 h / Inert atmosphere; Reflux
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethyl acetate / 24 h / 20 °C
With
sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
ethyl acetate; N,N-dimethyl-formamide; toluene;
2: intramolecular Diels-Alder reaction;
DOI:10.1016/j.tet.2011.11.060
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydride / dichloromethane; N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
3: sodium hydrogencarbonate / toluene / 18 h / Inert atmosphere; Reflux
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethyl acetate / 24 h / 20 °C
With
sodium hydride; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;
3: intramolecular Diels-Alder reaction;
DOI:10.1016/j.tet.2011.11.060
