cis-3-[2-(E,Z)-chloro-3,3,3trifluoropropenyl]-2,2-dimethylcyclopropanecarboxylic acid

Base Information

• Chemical Name: cis-3-[2-(E,Z)-chloro-3,3,3trifluoropropenyl]-2,2-dimethylcyclopropanecarboxylic acid
• CAS No.: 259823-89-7
• Molecular Formula: C₉H₁₀ClF₃O₂
• Molecular Weight: 242.625
• Mol file: 259823-89-7.mol

Synonyms:cis-3-[2-(E,Z)-chloro-3,3,3trifluoropropenyl]-2,2-dimethylcyclopropanecarboxylic acid

Chemical Property of cis-3-[2-(E,Z)-chloro-3,3,3trifluoropropenyl]-2,2-dimethylcyclopropanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-3-[2-(E,Z)-chloro-3,3,3trifluoropropenyl]-2,2-dimethylcyclopropanecarboxylic acid

There total 1 articles about cis-3-[2-(E,Z)-chloro-3,3,3trifluoropropenyl]-2,2-dimethylcyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.9%

(1S,3S)-3-((E)-2-Chloro-3,3,3-trifluoro-propenyl)-2,2-dimethyl-cyclopropanecarboxylic acid (S)-cyano-(3-phenoxy-phenyl)-methyl ester → 2-hydroxy-2-(3-phenoxyphenyl)acetonitrile (39515-47-4) + cis-3-[2-(E,Z)-chloro-3,3,3trifluoropropenyl]-2,2-dimethylcyclopropanecarboxylic acid (259823-89-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 36h; Heating;

DOI:10.1021/jf970438r

Reference yield:

cis-3-[2-(E,Z)-chloro-3,3,3trifluoropropenyl]-2,2-dimethylcyclopropanecarboxylic acid (259823-89-7) → (E)-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-((3-cyano-1-phenyl-1H-pyrazol-5-yl)carbamothioyl)-2,2-dimethylcyclopropane carboxamide

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 5 h / Reflux

2: acetonitrile / 4 h / 20 °C

3: acetonitrile / 10 h / Reflux

With thionyl chloride; In acetonitrile;

DOI:10.1080/10426507.2017.1292272

Reference yield:

cis-3-[2-(E,Z)-chloro-3,3,3trifluoropropenyl]-2,2-dimethylcyclopropanecarboxylic acid (259823-89-7) → (E)-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-N-((3-cyano-1-(o-tolyl)-1H-pyrazol-5-yl)carbamothioyl)-2,2-dimethylcyclopropane carboxamide

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 5 h / Reflux

2: acetonitrile / 4 h / 20 °C

3: acetonitrile / 10 h / Reflux

With thionyl chloride; In acetonitrile;

DOI:10.1080/10426507.2017.1292272

Downstream raw materials:

cyhalothroyl chloride

Refernces