5-(cyclopropyl-hydroxy-methyl)-3-methoxy-2-(2,4,6-trimethyl-phenyl)-cyclopent-2-enone

Base Information

Chemical Name:5-(cyclopropyl-hydroxy-methyl)-3-methoxy-2-(2,4,6-trimethyl-phenyl)-cyclopent-2-enone
CAS No.:1260628-50-9
Molecular Formula:C₁₉H₂₄O₃
Molecular Weight:300.398
Hs Code.:

Synonyms:5-(cyclopropyl-hydroxy-methyl)-3-methoxy-2-(2,4,6-trimethyl-phenyl)-cyclopent-2-enone

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Chemical Property of 5-(cyclopropyl-hydroxy-methyl)-3-methoxy-2-(2,4,6-trimethyl-phenyl)-cyclopent-2-enone

Chemical Property:

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Technology Process of 5-(cyclopropyl-hydroxy-methyl)-3-methoxy-2-(2,4,6-trimethyl-phenyl)-cyclopent-2-enone

There total 1 articles about 5-(cyclopropyl-hydroxy-methyl)-3-methoxy-2-(2,4,6-trimethyl-phenyl)-cyclopent-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84629-38-9
3-methoxy-2-(2,4,6-trimethylphenyl)-cyclopent-2-en-1-one

: 1489-69-6
Cyclopropanecarboxaldehyde

: 1260628-50-9
5-(cyclopropyl-hydroxy-methyl)-3-methoxy-2-(2,4,6-trimethyl-phenyl)-cyclopent-2-enone

Guidance literature:: 3-methoxy-2-(2,4,6-trimethylphenyl)-cyclopent-2-en-1-one; With lithium diisopropyl amide; In tetrahydrofuran; hexane; ethylbenzene; at -78 ℃; for 1h; Inert atmosphere;

Cyclopropanecarboxaldehyde; In tetrahydrofuran; hexane; ethylbenzene; at -78 - 20 ℃; for 4h; Inert atmosphere;

With water; In tetrahydrofuran; hexane; ethylbenzene;

Reference yield:

: 1260628-50-9
5-(cyclopropyl-hydroxy-methyl)-3-methoxy-2-(2,4,6-trimethyl-phenyl)-cyclopent-2-enone

: 124-63-0
methanesulfonyl chloride

: C₂₀H₂₆O₅S

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1260628-50-9
5-(cyclopropyl-hydroxy-methyl)-3-methoxy-2-(2,4,6-trimethyl-phenyl)-cyclopent-2-enone

: 1260626-28-5
4-cyclopropylmethyl-2-(2,4,6-trimethyl-phenyl)cyclopentane-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: potassium carbonate / methanol / 2 h / 20 °C

3: morpholine / 17 h / 100 °C

4: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 1.5 h / 1125.11 Torr

With morpholine; hydrogen; potassium carbonate; triethylamine; 5% Pd(II)/C(eggshell); In methanol; dichloromethane;