2-[N-(9-fluorenylmethyloxycarbonyl)-aminooxy]-N-{2-hydroxy-3-(4,4'-dimethoxytrityloxy)-propyl}acetamide

Base Information

• Chemical Name: 2-[N-(9-fluorenylmethyloxycarbonyl)-aminooxy]-N-{2-hydroxy-3-(4,4'-dimethoxytrityloxy)-propyl}acetamide
• CAS No.: 1187430-31-4
• Molecular Formula: C₄₁H₄₀N₂O₈
• Molecular Weight: 688.777

Synonyms:2-[N-(9-fluorenylmethyloxycarbonyl)-aminooxy]-N-{2-hydroxy-3-(4,4'-dimethoxytrityloxy)-propyl}acetamide

Chemical Property of 2-[N-(9-fluorenylmethyloxycarbonyl)-aminooxy]-N-{2-hydroxy-3-(4,4'-dimethoxytrityloxy)-propyl}acetamide

Chemical Property:

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Technology Process of 2-[N-(9-fluorenylmethyloxycarbonyl)-aminooxy]-N-{2-hydroxy-3-(4,4'-dimethoxytrityloxy)-propyl}acetamide

There total 1 articles about 2-[N-(9-fluorenylmethyloxycarbonyl)-aminooxy]-N-{2-hydroxy-3-(4,4'-dimethoxytrityloxy)-propyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(N-(9-fluorenylmethyloxycarbonyl)aminooxy)-N-(2,3-dihydroxypropyl)acetamide (1187430-27-8) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 2-[N-(9-fluorenylmethyloxycarbonyl)-aminooxy]-N-{2-hydroxy-3-(4,4'-dimethoxytrityloxy)-propyl}acetamide (1187430-31-4)

Guidance literature:

With pyridine; dmap; at 20 ℃;

DOI:10.1016/j.bmc.2009.06.038

Reference yield: 95.0%

succinic acid anhydride (108-30-5) + 2-[N-(9-fluorenylmethyloxycarbonyl)-aminooxy]-N-{2-hydroxy-3-(4,4'-dimethoxytrityloxy)-propyl}acetamide (1187430-31-4) → C45H44N2O11 (1187430-37-0)

Guidance literature:

succinic acid anhydride; 2-[N-(9-fluorenylmethyloxycarbonyl)-aminooxy]-N-{2-hydroxy-3-(4,4'-dimethoxytrityloxy)-propyl}acetamide; With dmap; triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h;

With water; citric acid; In methanol; 1,2-dichloro-ethane;

DOI:10.1016/j.bmc.2009.06.038

Reference yield: 82.0%

2-[N-(9-fluorenylmethyloxycarbonyl)-aminooxy]-N-{2-hydroxy-3-(4,4'-dimethoxytrityloxy)-propyl}acetamide (1187430-31-4) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → C50H57N4O9P (1187430-35-8)

Guidance literature:

With 1H-tetrazole; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2009.06.038

upstream raw materials:

2-(N-(9-fluorenylmethyloxycarbonyl)aminooxy)-N-(2,3-dihydroxypropyl)acetamide

4,4'-dimethoxytrityl chloride

Downstream raw materials:

C₄₅H₄₄N₂O₁₁

C₅₀H₅₇N₄O₉P

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