4,5-Difluoro-2-methyl-1h-indole

Base Information

Chemical Name:4,5-Difluoro-2-methyl-1h-indole
CAS No.:85462-60-8
Molecular Formula:C₉H₇F₂N
Molecular Weight:167.158
Hs Code.:2933990090
European Community (EC) Number:676-095-3
DSSTox Substance ID:DTXSID80525903
Wikidata:Q72463433
Mol file:85462-60-8.mol

Synonyms:4,5-Difluoro-2-methylindole;85462-60-8;4,5-difluoro-2-methyl-1h-indole;2-METHYL-4,5-DIFLUOROINDOLE;SCHEMBL12475636;DTXSID80525903;LTYZOUVRTGPHQM-UHFFFAOYSA-N;AMY14411;MFCD03839913;4 pound not5-Difluoro-2-methylindole;AKOS006346717;AB16306;AC-6648;DS-1444;CS-0172173;Q-102088

Suppliers and Price of 4,5-Difluoro-2-methyl-1h-indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4,5-Difluoro-2-methylindole
10mg
$ 45.00

SynQuest Laboratories
4,5-Difluoro-2-methylindole 95%
1 g
$ 944.00

SynQuest Laboratories
4,5-Difluoro-2-methylindole 95%
250 mg
$ 384.00

Matrix Scientific
4,5-Difluoro-2-methylindole >95%
1g
$ 478.00

Crysdot
4,5-Difluoro-2-methylindole 95+%
1g
$ 199.00

Chemenu
4,5-Difluoro-2-methylindole 95%
1g
$ 278.00

Apolloscientific
4,5-Difluoro-2-methylindole 95%
250mg
$ 240.00

Apolloscientific
4,5-Difluoro-2-methylindole 95%
1g
$ 590.00

American Custom Chemicals Corporation
4,5-DIFLUORO-2-METHYLINDOLE 95.00%
1G
$ 968.99

Alichem
4,5-Difluoro-2-methylindole
250mg
$ 247.20

Total 46 raw suppliers

Chemical Property of 4,5-Difluoro-2-methyl-1h-indole

Chemical Property:

Vapor Pressure:0.00858mmHg at 25°C
Refractive Index:1.6
Boiling Point:275.4 °C at 760 mmHg
Flash Point:120.3 °C
PSA：15.79000
Density:1.32 g/cm³
LogP:2.75450
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:167.05465555
Heavy Atom Count:12
Complexity:174

Purity/Quality:

97% ^*data from raw suppliers

4,5-Difluoro-2-methylindole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(N1)C=CC(=C2F)F

Technology Process of 4,5-Difluoro-2-methyl-1h-indole

There total 3 articles about 4,5-Difluoro-2-methyl-1h-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 132142-65-5
7-Bromo-3-ethylthio-4,5-difluoro-2-methylindole

: 85462-60-8
4,5-Difluoro-2-methylindole

Guidance literature:: With nickel; In ethanol; for 3h; Heating;
DOI:10.1248/cpb.38.2459

Reference yield:

: 64695-79-0
2-bromo-4,5-difluoro-aniline

: 85462-60-8
4,5-Difluoro-2-methylindole

Guidance literature:: Multi-step reaction with 2 steps

2: 86 percent / Raney nickel / ethanol / 3 h / Heating

With nickel; In ethanol;
DOI:10.1248/cpb.38.2459

Reference yield:

: 3863-11-4
3,4-difluoroaniline

: 85462-60-8
4,5-Difluoro-2-methylindole

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / Br₂, K₂CO₃ / CH₂Cl₂ / 0.5 h / -15 °C

3: 86 percent / Raney nickel / ethanol / 3 h / Heating

With bromine; nickel; potassium carbonate; In ethanol; dichloromethane;
DOI:10.1248/cpb.38.2459