4,5-difluoro-2,3-dihydro-2-Methyl-1H-Indole

Base Information

• Chemical Name: 4,5-difluoro-2,3-dihydro-2-Methyl-1H-Indole
• CAS No.: 85730-59-2
• Molecular Formula: C9H9 F2 N
• Molecular Weight: 169.17100
• Mol file: 85730-59-2.mol

Synonyms:(?à)-4,5-Difluoro-2-methyl-2,3-dihydroindole

Chemical Property of 4,5-difluoro-2,3-dihydro-2-Methyl-1H-Indole

Chemical Property:

• PSA: 12.03000
• LogP: 2.45930

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-difluoro-2,3-dihydro-2-Methyl-1H-Indole

There total 4 articles about 4,5-difluoro-2,3-dihydro-2-Methyl-1H-Indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4,5-Difluoro-2-methylindole (85462-60-8) → 4,5-difluoro-2-methyl-2,3-dihydro-1H-indole (85730-59-2)

Guidance literature:

With hydrogenchloride; tin; In acetic acid; for 2h; Heating;

DOI:10.1248/cpb.38.2459

Reference yield:

2-bromo-4,5-difluoro-aniline (64695-79-0) → 4,5-difluoro-2-methyl-2,3-dihydro-1H-indole (85730-59-2)

Guidance literature:

Multi-step reaction with 3 steps

2: 86 percent / Raney nickel / ethanol / 3 h / Heating

3: 85 percent / conc. HCl, Sn / acetic acid / 2 h / Heating

With hydrogenchloride; tin; nickel; In ethanol; acetic acid;

DOI:10.1248/cpb.38.2459

Reference yield:

7-Bromo-3-ethylthio-4,5-difluoro-2-methylindole (132142-65-5) → 4,5-difluoro-2-methyl-2,3-dihydro-1H-indole (85730-59-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / Raney nickel / ethanol / 3 h / Heating

2: 85 percent / conc. HCl, Sn / acetic acid / 2 h / Heating

With hydrogenchloride; tin; nickel; In ethanol; acetic acid;

DOI:10.1248/cpb.38.2459

upstream raw materials:

4,5-Difluoro-2-methylindole

2-bromo-4,5-difluoro-aniline

7-Bromo-3-ethylthio-4,5-difluoro-2-methylindole

3,4-difluoroaniline

Downstream raw materials:

(-)-4,5-difluoro-2-(S)-methyl-1-[(S)-N-p-toluenesulfonylprolyl]-2,3-dihydroindole

8,9-difluoro-2-methyl-6-oxo-1,2-dihydropyrrolo<3,2-ij>quinoline-5-carboxylic acid

Refernces

• 1、 Ishikawa,Uno,Miyamoto,Ueda,Tamaoka,Tominaga,Nakagawa. "Studies on antibacterial agents. II. Synthesis and antibacterial activities of substituted 1,2-dihydro-6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acids". . p. 2459 - 2462. Retrieved 2007/10/02.