(2R)-5-acetoxy-1,2-(isopropylidenedioxy)-9-(4-methoxybenzyloxy)non-6-yne

Base Information

Chemical Name:(2R)-5-acetoxy-1,2-(isopropylidenedioxy)-9-(4-methoxybenzyloxy)non-6-yne
CAS No.:851532-54-2
Molecular Formula:C₂₂H₃₀O₆
Molecular Weight:390.477
Hs Code.:

Synonyms:(2R)-5-acetoxy-1,2-(isopropylidenedioxy)-9-(4-methoxybenzyloxy)non-6-yne

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Chemical Property of (2R)-5-acetoxy-1,2-(isopropylidenedioxy)-9-(4-methoxybenzyloxy)non-6-yne

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Technology Process of (2R)-5-acetoxy-1,2-(isopropylidenedioxy)-9-(4-methoxybenzyloxy)non-6-yne

There total 6 articles about (2R)-5-acetoxy-1,2-(isopropylidenedioxy)-9-(4-methoxybenzyloxy)non-6-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 108-24-7
acetic anhydride

: 851532-53-1
(2R)-5-hydroxy-1,2-(isopropylidenedioxy)-9-(4-methoxybenzyloxy)non-6-yne

: 851532-54-2
(2R)-5-acetoxy-1,2-(isopropylidenedioxy)-9-(4-methoxybenzyloxy)non-6-yne

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tetasy.2005.01.045

Reference yield:

: 36326-38-2,64520-58-7,91057-97-5,91926-90-8,104321-62-2,124818-64-0,128525-67-7,128525-69-9,104321-63-3,917877-01-1
ethyl (R,Z)-3-(2′,2′-dimethyl-1′,3′-dioxolan-4′-yl)acrylate

: 851532-54-2
(2R)-5-acetoxy-1,2-(isopropylidenedioxy)-9-(4-methoxybenzyloxy)non-6-yne

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / H₂ / PtO₂ / ethyl acetate / 4 h / 20 °C

2.1: 97 percent / LiAlH₄ / tetrahydrofuran / 3 h / 0 - 20 °C

3.1: IBX / dimethylsulfoxide / 4 h / 0 - 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

4.2: 55 percent / tetrahydrofuran; hexane / -78 - 20 °C

5.1: 77 percent / Et₃N; DMAP / CH₂Cl₂ / 0 - 20 °C

With dmap; lithium aluminium tetrahydride; n-butyllithium; hydrogen; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; platinum(IV) oxide; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.tetasy.2005.01.045

Reference yield:

: 22323-80-4
(4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde

: 851532-54-2
(2R)-5-acetoxy-1,2-(isopropylidenedioxy)-9-(4-methoxybenzyloxy)non-6-yne

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 9 h / 20 °C

2.1: 99 percent / H₂ / PtO₂ / ethyl acetate / 4 h / 20 °C

3.1: 97 percent / LiAlH₄ / tetrahydrofuran / 3 h / 0 - 20 °C

4.1: IBX / dimethylsulfoxide / 4 h / 0 - 20 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.2: 55 percent / tetrahydrofuran; hexane / -78 - 20 °C

6.1: 77 percent / Et₃N; DMAP / CH₂Cl₂ / 0 - 20 °C

With dmap; lithium aluminium tetrahydride; n-butyllithium; hydrogen; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; platinum(IV) oxide; In tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; 1.1: Wittig olefination;
DOI:10.1016/j.tetasy.2005.01.045