(E)-3-(2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-ACRYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: (E)-3-(2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-ACRYLIC ACID ETHYL ESTER
• CAS No.: 36326-38-2
• Molecular Formula: C10H16 O4
• Molecular Weight: 200.235
• Hs Code.: 2932999099
• Mol file: 36326-38-2.mol

Synonyms:2-Propenoicacid, 3-(2,2-dimethyl-1,3-dioxolan-4-yl)-, ethyl ester, (S)-; Ethyl 3-((4S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-propenoate

Chemical Property of (E)-3-(2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-ACRYLIC ACID ETHYL ESTER

Chemical Property:

• Boiling Point: 241.0±0.0 °C(Predicted)
• PSA: 44.76000
• Density: 1.102±0.06 g/cm3(Predicted)
• LogP: 1.25720

Purity/Quality:

NLT 98% ^*data from raw suppliers

Ethyl3-((4S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-propenoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-3-(2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-ACRYLIC ACID ETHYL ESTER

There total 39 articles about (E)-3-(2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-ACRYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + (4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde (22323-80-4) → ethyl (R,Z)-3-(2′,2′-dimethyl-1′,3′-dioxolan-4′-yl)acrylate (36326-38-2,64520-58-7,91057-97-5,91926-90-8,104321-62-2,124818-64-0,128525-67-7,128525-69-9,104321-63-3,917877-01-1) + ethyl (E)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate (36326-38-2,64520-58-7,91057-97-5,91926-90-8,104321-63-3,124818-64-0,128525-67-7,128525-69-9,104321-62-2,917877-01-1)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; water; at 20 ℃; for 17h; pH=11.6;

DOI:10.1021/ol052554i

Reference yield: 78.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + (4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde (22323-80-4) → ethyl (R,Z)-3-(2′,2′-dimethyl-1′,3′-dioxolan-4′-yl)acrylate (36326-38-2,64520-58-7,91057-97-5,91926-90-8,104321-62-2,124818-64-0,128525-67-7,128525-69-9,104321-63-3,917877-01-1) + ethyl (E)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate (36326-38-2,64520-58-7,91057-97-5,91926-90-8,104321-63-3,124818-64-0,128525-67-7,128525-69-9,104321-62-2,917877-01-1)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; water; at 20 ℃; for 17h; pH=11.6;

DOI:10.1021/ol052554i

Reference yield: 74.0%

ethyl (triphenylphosphoranylidene)acetate (1099-45-2) + (4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde (22323-80-4) → ethyl (R,Z)-3-(2′,2′-dimethyl-1′,3′-dioxolan-4′-yl)acrylate (36326-38-2,64520-58-7,91057-97-5,91926-90-8,104321-62-2,124818-64-0,128525-67-7,128525-69-9,104321-63-3,917877-01-1) + ethyl (E)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate (36326-38-2,64520-58-7,91057-97-5,91926-90-8,104321-63-3,124818-64-0,128525-67-7,128525-69-9,104321-62-2,917877-01-1)

Guidance literature:

In benzene; Reflux;

DOI:10.1021/jo202054g

upstream raw materials:

sodium ethanolate

methyl (S)-4,5-dihydroxy-4,5-O-isopropylidene-2-pentenoate

diethoxyphosphoryl-acetic acid ethyl ester

2,3-isopropylidene-glyceraldehyde

Downstream raw materials:

(5S)-5-(hydroxymethyl)-5H-furan-2-one

methyl (2E)-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate

(4S)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propan-1-ol

(S)-6-(benzyloxy)hex-1-en-3-ol