2-Benzyloxycyclobutanone

Base Information

• Chemical Name: 2-Benzyloxycyclobutanone
• CAS No.: 206751-75-9
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.215
• Hs Code.: 2914500090
• European Community (EC) Number: 837-556-6
• Mol file: 206751-75-9.mol

Synonyms:2-Benzyloxycyclobutanone;206751-75-9;2-(benzyloxy)cyclobutanone;2-(benzyloxy)cyclobutan-1-one;2-phenylmethoxycyclobutan-1-one;Cyclobutanone, 2-(phenylmethoxy)-;MFCD09908029;2-Benzyloxy-cyclobutanone;SCHEMBL1797263;HRPGUVFWKDCSSX-UHFFFAOYSA-N;AKOS006310534;SB11342;AS-50673;SY098921;CS-0052247;FT-0757387;EN300-116411;P10844

Chemical Property of 2-Benzyloxycyclobutanone

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 176.083729621
• Heavy Atom Count: 13
• Complexity: 183

Purity/Quality:

97% ^*data from raw suppliers

2-Benzyloxycyclobutanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(=O)C1OCC2=CC=CC=C2

Technology Process of 2-Benzyloxycyclobutanone

There total 5 articles about 2-Benzyloxycyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(2,2-dimethoxy-cyclobutoxymethyl)-benzene → α-benzyloxycyclobutanone (206751-75-9)

Guidance literature:

With sulfuric acid; silica gel; In dichloromethane;

DOI:10.1016/j.tetasy.2006.05.014

Reference yield: 88.0%

2-hydroxycyclobutanone (99440-99-0) + benzyl alcohol (100-51-6,185532-71-2) → α-benzyloxycyclobutanone (206751-75-9)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 40 ℃; for 48h; Reagent/catalyst; Solvent; chemoselective reaction; Catalytic behavior; Green chemistry;

DOI:10.1039/c7ob02545a

Reference yield: 62.0%

1,2-bis(trimethylsiloxy)cyclobutene (17082-61-0) + benzyl alcohol (100-51-6,185532-71-2) → α-benzyloxycyclobutanone (206751-75-9)

Guidance literature:

With hydrogenchloride; In diethyl ether; water; at 0 - 80 ℃;

DOI:10.1016/j.bmcl.2010.02.048

upstream raw materials:

1,2-bis(trimethylsiloxy)cyclobutene

benzyl alcohol

benzyl bromide

2-hydroxycyclobutanone