(1R,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile

Base Information

• Chemical Name: (1R,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile
• CAS No.: 905916-02-1
• Molecular Formula: C₂₀H₂₂N₂O
• Molecular Weight: 306.407

Synonyms:(1R,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile

Chemical Property of (1R,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of (1R,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile

There total 4 articles about (1R,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

(S)-1-phenyl-ethylamine (2627-86-3) + sodium cyanide (143-33-9,25596-52-5) + (R)-(+)-2-benzyloxycyclobutanone → (1R,2R,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile (905916-00-9) + (1R,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile (905916-02-1) + (1S,2R,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile (905916-03-2) + (1S,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile (905916-01-0)

Guidance literature:

With acetic acid; In dimethyl sulfoxide; at 20 ℃; for 4h;

DOI:10.1016/j.tetasy.2006.05.014

Reference yield: 40.0%

(S)-1-phenyl-ethylamine (2627-86-3) + sodium cyanide (143-33-9,25596-52-5) + (S)-(-)-2-benzyloxycyclobutanone (737758-92-8) → (1R,2R,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile (905916-00-9) + (1R,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile (905916-02-1) + (1S,2R,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile (905916-03-2) + (1S,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile (905916-01-0)

Guidance literature:

With acetic acid; In dimethyl sulfoxide; at 20 ℃; for 5h;

DOI:10.1016/j.tetasy.2006.05.014

Reference yield:

(1S,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile (905916-01-0) → (1R,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile (905916-02-1)

Guidance literature:

With zinc dibromide; In dimethyl sulfoxide; at 45 ℃;

DOI:10.1016/j.tetasy.2006.05.014

upstream raw materials:

(1S,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile

(S)-1-phenyl-ethylamine

sodium cyanide

α-benzyloxycyclobutanone

Downstream raw materials:

(1S,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarboxamide

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