N-(4-{(1R)-1-[(R)-(tert-butylsulfinyl)amino]ethyl}-2-chlorophenyl)methanesulfonamide

Base Information

Chemical Name:N-(4-{(1R)-1-[(R)-(tert-butylsulfinyl)amino]ethyl}-2-chlorophenyl)methanesulfonamide
CAS No.:1321964-81-1
Molecular Formula:C₁₃H₂₁ClN₂O₃S₂
Molecular Weight:352.906
Hs Code.:

Synonyms:N-(4-{(1R)-1-[(R)-(tert-butylsulfinyl)amino]ethyl}-2-chlorophenyl)methanesulfonamide

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Chemical Property of N-(4-{(1R)-1-[(R)-(tert-butylsulfinyl)amino]ethyl}-2-chlorophenyl)methanesulfonamide

Chemical Property:

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Technology Process of N-(4-{(1R)-1-[(R)-(tert-butylsulfinyl)amino]ethyl}-2-chlorophenyl)methanesulfonamide

There total 3 articles about N-(4-{(1R)-1-[(R)-(tert-butylsulfinyl)amino]ethyl}-2-chlorophenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₉ClN₂O₃S₂

: 1321964-81-1
N-(4-{(1R)-1-[(R)-(tert-butylsulfinyl)amino]ethyl}-2-chlorophenyl)methanesulfonamide

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; at -30 - -10 ℃; for 17h; optical yield given as %de; diastereoselective reaction;
DOI:10.1021/op200177b

Reference yield:

: 2923-66-2
3-chloro-4-fluoroacetophenone

: 1321964-81-1
N-(4-{(1R)-1-[(R)-(tert-butylsulfinyl)amino]ethyl}-2-chlorophenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 16 h / 120 °C

2: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / Reflux

3: sodium tetrahydroborate / tetrahydrofuran / 17 h / -30 - -10 °C

With titanium(IV) tetraethanolate; sodium tetrahydroborate; potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/op200177b

Reference yield:

: N-(4-acetyl-2-chlorophenyl)methanesulfonamide

: 1321964-81-1
N-(4-{(1R)-1-[(R)-(tert-butylsulfinyl)amino]ethyl}-2-chlorophenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / Reflux

2: sodium tetrahydroborate / tetrahydrofuran / 17 h / -30 - -10 °C

With titanium(IV) tetraethanolate; sodium tetrahydroborate; In tetrahydrofuran;
DOI:10.1021/op200177b