2923-66-2

Basic information

• Product Name: 3-Chloro-4-fluoroacetophenone
• Synonyms: 3'-CHLORO-4'-FLUOROACETOPHENONE;3-CHLORO-4-FLUOROACETOPHENONE;1-(3-CHLORO-4-FLUOROPHENYL)ETHAN-1-ONE;1-(3-Chloro-4-fluorophenyl)ethanone;3'-Chloro-4'-fluoroacetophenone 97%;3'-Chloro-4'-fluoroacetophenone97%;1-(3-chloro-4-fluorophenyl)acetic acid;3'-Chloro-4'-fluoroacetophenone(3-Chloro-4-fluoroacetophenone) ,98%
• CAS NO: 2923-66-2
• Molecular Formula: C₈H₆ClFO
• Molecular Weight: 172.58
• EINECS: -0
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Adehydes, Acetals & Ketones;Chlorine Compounds;Fluorine Compounds;Fluorine series
• Mol File: 2923-66-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 42 °C
• Boiling Point: 126 °C
• Flash Point: 126-127°C/15mm
• Appearance: /
• Density: 1.259 g/cm³
• Vapor Pressure: 200mmHg at 25°C
• Refractive Index: 1.247
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• BRN: 3117772
• CAS DataBase Reference: 3-Chloro-4-fluoroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-fluoroacetophenone(2923-66-2)
• EPA Substance Registry System: 3-Chloro-4-fluoroacetophenone(2923-66-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 2923-66-2(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

3''-Chloro-4''-fluoroacetophenone

InChI:InChI=1/C2HF3O/c3-1(4)2(5)6/h1H

Upstream product

• 348-51-6 1-chloro-2-fluorobenzene 
• 75-36-5 acetyl chloride 

Downstream Products

• 127055-76-9 (E)-1-(3-Chloro-4-fluoro-phenyl)-3-(2-chloro-phenyl)-propenone 
• 38440-12-9 1-(3-chloro-4-fluorophenyl) butane-1,3-dione 
• 78864-24-1 [5-(3-chloro-4-fluoro-phenyl)-thiazol-2-yl]-(4-chloro-phenyl)-amine 
• 705-79-3 2-(3-chloro-4-fluorophenyl)acetic acid 
• 205124-82-9 6-(3-Chloro-4-fluoro-phenyl)-4-methylsulfanyl-2-oxo-2H-pyran-3-carboxylic acid methyl ester 
• 440363-95-1 3-[2-(3-Chloro-4-fluoro-phenyl)-2-oxo-eth-(E)-ylidene]-7-nitro-1,3-dihydro-indol-2-one 
• 440363-91-7 3-[2-(3-chloro-4-fluoro-phenyl)-2-oxo-ethyl]-3-hydroxy-7-nitro-1,3-dihydro-indol-2-one 
• 861964-90-1 1-(3-chloro-4-fluorophenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)propan-1-one 
• 1147939-72-7 2-(3-chloro-4-fluorophenyl)-2-methyloxirane 
• 1266519-47-4 1-{[4-(3-chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-yl]carbonyl}imidazolidin-4-one 
• 1266519-66-7 3-{4-(3-chloro-4-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-5-yl}fluorobenzenecarbonitrile 
• 1266519-92-9 ethyl 4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylate 
• 1266519-94-1 ethyl 5-bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylate 
• 878572-03-3 1-(3-chloro-4-fluorophenyl)ethan-1-ol 

Relevant articles and documents

2-Hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl] -1-benzenesulfonamide (DRF-4367): An orally active COX-2 inhibitor identified through pharmacophoric modulation

Analogs of 1,5-diarylpyrazoles with a novel pharmacophore at N1 were designed, synthesized and evaluated for the in-vitro cyclooxygenase (COX-1/COX-2) inhibitory activity. The variations at/around position-4 of the C-5 phenyl ring in conjunction with a CF3 and CHF2 groups at C-3 exhibited a high degree of potency and selectivity index (SI) for COX-2 inhibition. The in-vivo evaluation of these potent compounds with a few earlier ones indicated the 4-OMe-phenyl analog 6 and the 4-NHMe-phenyl analog 9 with a CF3, and the 4-OEt-phenyl analog 19 with a CHF2 group at C-3 to possess superior potency than celecoxib. In addition to its impressive anti-inflammatory, antipyretic, analgesic and anti-arthritic properties, compound 6 (DRF-4367) was found to possess an excellent pharmacokinetic profile, gastrointestinal (GI) safety in the long-term arthritis study and COX-2 potency in human whole blood assay. Thus, compound 6 was selected as an orally active anti-inflammatory candidate for pre-clinical evaluation.