1-(5-isopropyl-2-methylphenoxy)-3-(N-(2-hydroxybenzyl)-N-(pyridine-2-ylmethyl)amino)propan-2-ol

Base Information

• Chemical Name: 1-(5-isopropyl-2-methylphenoxy)-3-(N-(2-hydroxybenzyl)-N-(pyridine-2-ylmethyl)amino)propan-2-ol
• CAS No.: 1350802-70-8
• Molecular Formula: C₂₆H₃₂N₂O₃
• Molecular Weight: 420.552
• Mol file: 1350802-70-8.mol

Synonyms:1-(5-isopropyl-2-methylphenoxy)-3-(N-(2-hydroxybenzyl)-N-(pyridine-2-ylmethyl)amino)propan-2-ol

Chemical Property of 1-(5-isopropyl-2-methylphenoxy)-3-(N-(2-hydroxybenzyl)-N-(pyridine-2-ylmethyl)amino)propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-isopropyl-2-methylphenoxy)-3-(N-(2-hydroxybenzyl)-N-(pyridine-2-ylmethyl)amino)propan-2-ol

There total 1 articles about 1-(5-isopropyl-2-methylphenoxy)-3-(N-(2-hydroxybenzyl)-N-(pyridine-2-ylmethyl)amino)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N-(2-pyridylmethyl)-2-hydroxybenzylamine (63671-68-1) + 2-((5-isopropyl-2-methylphenoxy)methyl)oxirane (60217-55-2) → 1-(5-isopropyl-2-methylphenoxy)-3-(N-(2-hydroxybenzyl)-N-(pyridine-2-ylmethyl)amino)propan-2-ol (1350802-70-8)

Guidance literature:

In methanol; at 70 ℃; for 8h;

DOI:10.1016/j.poly.2011.06.032

Reference yield: 78.0%

1-(5-isopropyl-2-methylphenoxy)-3-(N-(2-hydroxybenzyl)-N-(pyridine-2-ylmethyl)amino)propan-2-ol (1350802-70-8) + iron(III) chloride (7705-08-0) → (1-(5-isopropyl-2-methyl phenoxy)-3-(N-2-dehydroxy benzyl-N-((pyridine-2-yl)amino))propan-2-ol)dichloroiron(III) (1352413-47-8)

Guidance literature:

With Et₃N; In methanol; ligand in CH3OH mixed with FeCl3 in CH3OH (L:Cu=1:1), refluxed for 5-8 h, treated with Et3N; cooled to room temp., filtered, washed (H2O, EtOH, ether), elem. anal.;

DOI:10.1016/j.poly.2011.06.032

Reference yield: 70.0%

nickel(II) chloride hexahydrate + 1-(5-isopropyl-2-methylphenoxy)-3-(N-(2-hydroxybenzyl)-N-(pyridine-2-ylmethyl)amino)propan-2-ol (1350802-70-8) → (1-(5-isopropyl-2-methyl phenoxy)-3-(N-2-dehydroxy benzyl-N-((pyridine-2-yl)amino))propan-2-ol)chloronickel(II) (1352413-45-6)

Guidance literature:

With Et₃N; In methanol; ligand in CH3OH mixed with NiCl2*6H2O in CH3OH (L:Cu=1:1), refluxed for 5-8 h, treated with Et3N; cooled to room temp., filtered, washed (H2O, EtOH, ether), elem. anal.;

DOI:10.1016/j.poly.2011.06.032

upstream raw materials:

N-(2-pyridylmethyl)-2-hydroxybenzylamine

2-((5-isopropyl-2-methylphenoxy)methyl)oxirane

Downstream raw materials:

(1-(5-isopropyl-2-methyl phenoxy)-3-(N-2-dehydroxy benzyl-N-((pyridine-2-yl)amino))propan-2-ol)chloronickel(II)

(1-(5-isopropyl-2-methyl phenoxy)-3-(N-2-dehydroxy benzyl-N-((pyridine-2-yl)amino))propan-2-ol)dichloroiron(III)

(1-(5-isopropyl-2-methyl phenoxy)-3-(N-2-dehydroxy benzyl-N-((pyridine-2-yl)amino))propan-2-ol)chlorozinc(II)