10.1016/j.tet.2014.03.072
The research focuses on the development of an iron-based catalytic system for the synthesis of primary, secondary, and tertiary amides through the Ritter reaction, as well as the addition of benzyl alcohols across phenylacetylene to produce substituted phenyl ketones. The purpose of this study was to improve and expand the substrate scope of the Ritter reaction, which is an atom-economical approach to amide synthesis, and to do so under mild reaction conditions that tolerate air and moisture. The conclusions drawn from the research indicate that the simple iron-catalyzed method is effective for accessing a range of amides and phenyl ketones, significantly outperforming previous methods in terms of yield. Key chemicals used in the process include iron(III) chloride (FeCl3), silver hexafluoroantimonate (AgSbF6), and acetonitrile, along with various alcohols and alkynes as substrates.
10.1016/j.bmcl.2012.05.007
The research focuses on the synthesis and biological evaluation of two recently isolated flavones, 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone (3a) and 5-carboethoxymethyl-4,7-dihydroxyflavone (3b), along with their derivatives (3c–t). The main objective was to assess the antimicrobial, antioxidant, and anticancer activities of these compounds. The synthesis was achieved through a series of reactions starting from methyl curvulinate (4), using two primary methods: the Baker-Venkatraman rearrangement and the chalcone route. Various reagents such as acid chloride, sodium hydride, and ferric chloride were employed, and the synthesized compounds were purified and characterized using techniques like column chromatography, NMR, and mass spectrometry. The biological activities were evaluated through different in vitro assays, including the modified microtiter broth dilution method for antibacterial activity, the well diffusion method for antifungal activity, and various antioxidant potential tests like DPPH radical scavenging, superoxide radical scavenging, lipid peroxidation inhibition, and erythrocyte hemolysis inhibition. The synthesized compounds were compared with standard drugs like neomycin and luteolin for their activity.
10.1021/ic001339p
The research focuses on the synthesis and characterization of chloroferric complexes derived from monosubstituted derivatives of the tris(2-pyridylmethyl)amine (TPA) ligand, specifically those substituted with a bulky bromine atom or a methoxyphenyl ring. The study aims to understand how the introduction of functional groups affects the structure and reactivity of iron complexes. The reactants used in the experiments include anhydrous FeCl3 and TPA derivatives, which upon reaction, yield yellow-orange complexes that are stable in air and solution. The complexes were analyzed using UV-vis and 1H NMR spectroscopy, and their crystal structures were determined through X-ray diffraction analysis. The results indicate that the substitution leads to tridentate coordination, with the substituted pyridine arm remaining uncoordinated and potentially reactive. The complexes exhibit high spin states and are stable, suggesting potential for further synthetic applications.
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