N-[2-methoxy-2-(3-methoxyphenyl)-2-(trifluoromethyl)ethyl]-4-(trifluoromethyl)cinnamic amide

Base Information

Chemical Name:N-[2-methoxy-2-(3-methoxyphenyl)-2-(trifluoromethyl)ethyl]-4-(trifluoromethyl)cinnamic amide
CAS No.:324075-46-9
Molecular Formula:C₂₁H₁₉F₆NO₃
Molecular Weight:447.377
Hs Code.:

Synonyms:N-[2-methoxy-2-(3-methoxyphenyl)-2-(trifluoromethyl)ethyl]-4-(trifluoromethyl)cinnamic amide

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Chemical Property of N-[2-methoxy-2-(3-methoxyphenyl)-2-(trifluoromethyl)ethyl]-4-(trifluoromethyl)cinnamic amide

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Technology Process of N-[2-methoxy-2-(3-methoxyphenyl)-2-(trifluoromethyl)ethyl]-4-(trifluoromethyl)cinnamic amide

There total 3 articles about N-[2-methoxy-2-(3-methoxyphenyl)-2-(trifluoromethyl)ethyl]-4-(trifluoromethyl)cinnamic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 105919-36-6,120681-07-4
trans-4-(trifluoromethyl)cinnamoyl chloride

: 324075-37-8
3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propylamine

: 324075-46-9
N-[2-methoxy-2-(3-methoxyphenyl)-2-(trifluoromethyl)ethyl]-4-(trifluoromethyl)cinnamic amide

Guidance literature:: With sodium carbonate; In diethyl ether; water; at 0 - 20 ℃; for 2h;
DOI:10.1016/S0040-4020(01)00836-5

Reference yield:

: 30724-22-2
2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone

: 324075-46-9
N-[2-methoxy-2-(3-methoxyphenyl)-2-(trifluoromethyl)ethyl]-4-(trifluoromethyl)cinnamic amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaCN / 1,2-dimethoxy-ethane / 0.5 h / 20 °C

1.2: 65 percent / 1,2-dimethoxy-ethane / 5 h / 60 °C

2.1: 61 percent / NaBH₄; CoCl₂ / methanol / 0 - 20 °C

3.1: 72 percent / Na₂CO₃ / diethyl ether; H₂O / 2 h / 0 - 20 °C

With sodium tetrahydroborate; sodium cyanide; sodium carbonate; In methanol; 1,2-dimethoxyethane; diethyl ether; water;
DOI:10.1016/S0040-4020(01)00836-5

Reference yield:

: 324075-44-7
3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propionitrile

: 324075-46-9
N-[2-methoxy-2-(3-methoxyphenyl)-2-(trifluoromethyl)ethyl]-4-(trifluoromethyl)cinnamic amide

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / NaBH₄; CoCl₂ / methanol / 0 - 20 °C

2: 72 percent / Na₂CO₃ / diethyl ether; H₂O / 2 h / 0 - 20 °C

With sodium tetrahydroborate; sodium carbonate; In methanol; diethyl ether; water;
DOI:10.1016/S0040-4020(01)00836-5