(R)-2-acetamido-3-methoxy-N-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzyl)propanamide

Base Information

Chemical Name:(R)-2-acetamido-3-methoxy-N-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzyl)propanamide
CAS No.:1197982-80-1
Molecular Formula:C₁₅H₁₇F₃N₄O₃
Molecular Weight:358.32
Hs Code.:

Synonyms:(R)-2-acetamido-3-methoxy-N-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzyl)propanamide

Suppliers and Price of (R)-2-acetamido-3-methoxy-N-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzyl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-acetamido-3-methoxy-N-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzyl)propanamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-2-acetamido-3-methoxy-N-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzyl)propanamide

There total 10 articles about (R)-2-acetamido-3-methoxy-N-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 196601-67-9
(R)-2-N-acetamido-3-methoxypropionic acid

: (4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)methanamine

: 1197982-80-1
(R)-2-acetamido-3-methoxy-N-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzyl)propanamide

Guidance literature:: With 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; at 20 ℃; for 16.16h;

Reference yield:

: 87736-75-2
1-<4-<(tert-butyldimethylsilyloxy)methyl>phenyl>-2,2,2-trifluoro-1-ethanone

: 1197982-80-1
(R)-2-acetamido-3-methoxy-N-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzyl)propanamide

Guidance literature:: Multi-step reaction with 9 steps

1: pyridine; hydroxylamine hydrochloride / 4 h / Reflux

2: dmap; triethylamine / dichloromethane / 20 °C

3: ammonia / diethyl ether / -78 - 20 °C

4: iodine; triethylamine / methanol / 3 h / 20 °C

5: hydrogenchloride / 1,4-dioxane; methanol / 3 h / 20 °C

6: methyl-triphenylphosphonium iodide / acetonitrile / 20 h / 20 °C

7: sodium azide / methanol / 6 h / 45 °C

8: triphenylphosphine polymer bound; water / tetrahydrofuran

9: 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran / 16.16 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; dmap; sodium azide; triphenylphosphine polymer bound; hydroxylamine hydrochloride; ammonia; water; iodine; methyl-triphenylphosphonium iodide; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; acetonitrile;

Reference yield:

: 87736-86-5
3-<4-<(tert-butyldimethylsiloxy)methyl>phenyl>-3-trifluoromethyl-3H-diazirine

: 1197982-80-1
(R)-2-acetamido-3-methoxy-N-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzyl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane; methanol / 3 h / 20 °C

2: methyl-triphenylphosphonium iodide / acetonitrile / 20 h / 20 °C

3: sodium azide / methanol / 6 h / 45 °C

4: triphenylphosphine polymer bound; water / tetrahydrofuran

5: 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran / 16.16 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium azide; triphenylphosphine polymer bound; water; methyl-triphenylphosphonium iodide; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; acetonitrile;