2-cyano-N-(4-fluoro-phenyl)-3-[1-(4-fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propanamide

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Chemical Name:2-cyano-N-(4-fluoro-phenyl)-3-[1-(4-fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propanamide
CAS No.:127477-05-8
Molecular Formula:C₂₆H₁₆F₂N₄O₂
Molecular Weight:454.435
Hs Code.:

Synonyms:2-cyano-N-(4-fluoro-phenyl)-3-[1-(4-fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propanamide

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Chemical Property of 2-cyano-N-(4-fluoro-phenyl)-3-[1-(4-fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propanamide

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Technology Process of 2-cyano-N-(4-fluoro-phenyl)-3-[1-(4-fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propanamide

There total 5 articles about 2-cyano-N-(4-fluoro-phenyl)-3-[1-(4-fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1195-45-5
para-fluorophenyl isocyanate

: 137776-05-7
3-[1-(4-Fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propionitrile

: 127477-05-8
2-cyano-N-(4-fluoro-phenyl)-3-[1-(4-fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propanamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; Ambient temperature;

Reference yield:

: 100397-38-4
ethyl β-(1-oxo-2,3-dihydro-1H-inden-2-yl)-α-oxoacetate

: 127477-05-8
2-cyano-N-(4-fluoro-phenyl)-3-[1-(4-fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 50 °C

2: 74 percent / NaH / dioxane / 55 °C

3: 92 percent / Et₃N / dimethylformamide / Ambient temperature

With sodium hydride; acetic acid; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 83-33-0
inden-1-one

: 127477-05-8
2-cyano-N-(4-fluoro-phenyl)-3-[1-(4-fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium ethoxide / ethanol

2: acetic acid / 50 °C

3: 74 percent / NaH / dioxane / 55 °C

4: 92 percent / Et₃N / dimethylformamide / Ambient temperature

With sodium ethanolate; sodium hydride; acetic acid; triethylamine; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;