3-[1-(4-Fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propionitrile

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Chemical Name:3-[1-(4-Fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propionitrile
CAS No.:137776-05-7
Molecular Formula:C₁₉H₁₂FN₃O
Molecular Weight:317.322
Hs Code.:

Synonyms:3-[1-(4-Fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propionitrile

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Chemical Property of 3-[1-(4-Fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propionitrile

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Technology Process of 3-[1-(4-Fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propionitrile

There total 3 articles about 3-[1-(4-Fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 60656-31-7
1-(4-fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazole-3-carboxylic acid ethyl ester

: 75-05-8,26809-02-9
acetonitrile

: 137776-05-7
3-[1-(4-Fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propionitrile

Guidance literature:: With sodium hydride; In 1,4-dioxane; at 55 ℃;

Reference yield:

: 100397-38-4
ethyl β-(1-oxo-2,3-dihydro-1H-inden-2-yl)-α-oxoacetate

: 137776-05-7
3-[1-(4-Fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 50 °C

2: 74 percent / NaH / dioxane / 55 °C

With sodium hydride; acetic acid; In 1,4-dioxane;

Reference yield:

: 83-33-0
inden-1-one

: 137776-05-7
3-[1-(4-Fluoro-phenyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-3-oxo-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium ethoxide / ethanol

2: acetic acid / 50 °C

3: 74 percent / NaH / dioxane / 55 °C

With sodium ethanolate; sodium hydride; acetic acid; In 1,4-dioxane; ethanol;