2-amino-9-<<2,2-bis-<(benzoyloxy)methyl>cyclopropyl>methyl>-6-chloropurine

Base Information

Chemical Name:2-amino-9-<<2,2-bis-<(benzoyloxy)methyl>cyclopropyl>methyl>-6-chloropurine
CAS No.:116664-09-6
Molecular Formula:C₂₅H₂₂ClN₅O₄
Molecular Weight:491.934
Hs Code.:

Synonyms:2-amino-9-<<2,2-bis-<(benzoyloxy)methyl>cyclopropyl>methyl>-6-chloropurine

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Chemical Property of 2-amino-9-<<2,2-bis-<(benzoyloxy)methyl>cyclopropyl>methyl>-6-chloropurine

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Technology Process of 2-amino-9-<<2,2-bis-<(benzoyloxy)methyl>cyclopropyl>methyl>-6-chloropurine

There total 6 articles about 2-amino-9-<<2,2-bis-<(benzoyloxy)methyl>cyclopropyl>methyl>-6-chloropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10310-21-1
2-Amino-6-chloropurin

: 116664-08-5
<2,2-bis<(benzoyloxy)methyl>cyclopropyl>methyl p-toluenesulfonate

: 116664-09-6
2-amino-9-<<2,2-bis-<(benzoyloxy)methyl>cyclopropyl>methyl>-6-chloropurine

: C₂₅H₂₂ClN₅O₄

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 4h;
DOI:10.1021/jm00120a010

Reference yield:

: 584-08-7
potassium carbonate

: 10310-21-1
2-Amino-6-chloropurin

: 116664-08-5
<2,2-bis<(benzoyloxy)methyl>cyclopropyl>methyl p-toluenesulfonate

: 116664-09-6
2-amino-9-<<2,2-bis-<(benzoyloxy)methyl>cyclopropyl>methyl>-6-chloropurine

Guidance literature:: In chloroform-methanol-water; N,N-dimethyl-formamide;

Reference yield:

: 7686-78-4
diethyl 2-vinylcyclopropane-1,1-dicarboxylate

: 116664-09-6
2-amino-9-<<2,2-bis-<(benzoyloxy)methyl>cyclopropyl>methyl>-6-chloropurine

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

2: 75 percent / pyridine / 2 h / Ambient temperature

3: 1.) ozone, 2.) NaBH₄ / 1.) CH₂Cl₂, -70 deg C, 30 min, 2.) 1.5 h

4: 54 percent / pyridine / 1.5 h / Ambient temperature

5: 53 percent / K₂CO₃ / dimethylformamide / 4 h / 60 °C

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; potassium carbonate; ozone; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;
DOI:10.1021/jm00120a010