Carbonic acid benzyl ester 5-fluoro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester

Base Information

• Chemical Name: Carbonic acid benzyl ester 5-fluoro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester
• CAS No.: 118004-25-4
• Molecular Formula: C₁₄H₁₃FN₂O₅
• Molecular Weight: 308.266
• Mol file: 118004-25-4.mol

Synonyms:Carbonic acid benzyl ester 5-fluoro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester

Chemical Property of Carbonic acid benzyl ester 5-fluoro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbonic acid benzyl ester 5-fluoro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester

There total 3 articles about Carbonic acid benzyl ester 5-fluoro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(benzyloxycarbonyloxymethyl)-5-fluorouracil (116097-53-1) + methyl iodide (74-88-4) → Carbonic acid benzyl ester 5-fluoro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester (118004-25-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile;

DOI:10.1246/cl.1988.1381

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → Carbonic acid benzyl ester 5-fluoro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester (118004-25-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / triethylamine / acetonitrile

2: 93 percent / ethyldiisopropylamine (EDA) / acetonitrile

With triethylamine; N-ethyl-N,N-diisopropylamine; In acetonitrile;

DOI:10.1246/cl.1988.1381

Reference yield:

N1,N3-bis(hydroxymethyl)-5-fluorouracil (74179-14-9) → Carbonic acid benzyl ester 5-fluoro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl ester (118004-25-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / triethylamine / acetonitrile

2: 93 percent / ethyldiisopropylamine (EDA) / acetonitrile

With triethylamine; N-ethyl-N,N-diisopropylamine; In acetonitrile;

DOI:10.1246/cl.1988.1381

upstream raw materials:

1-(benzyloxycarbonyloxymethyl)-5-fluorouracil

methyl iodide

benzyl chloroformate

N¹,N³-bis(hydroxymethyl)-5-fluorouracil

Downstream raw materials:

5-fluoro-3-methyl-1H-pyrimidine-2,4-dione