3-(1'-nitromethyl-3-phenylpropyl)-1H-indole

Base Information

• Chemical Name: 3-(1'-nitromethyl-3-phenylpropyl)-1H-indole
• CAS No.: 1167436-57-8
• Molecular Formula: C₁₈H₁₈N₂O₂
• Molecular Weight: 294.353
• Mol file: 1167436-57-8.mol

Synonyms:3-(1'-nitromethyl-3-phenylpropyl)-1H-indole

Chemical Property of 3-(1'-nitromethyl-3-phenylpropyl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1'-nitromethyl-3-phenylpropyl)-1H-indole

There total 3 articles about 3-(1'-nitromethyl-3-phenylpropyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

indole (120-72-9) + (E)-(4-nitrobut-3-enyl)benzene (80922-14-1) → 3-(1'-nitromethyl-3-phenylpropyl)-1H-indole (1167436-57-8)

Guidance literature:

With C₁₅H₁₀N₂O₅^(2-)*5C₃H₇NO*Zn₄O⁽²⁺⁾; In toluene; at 60 ℃; for 24h;

DOI:10.1002/cctc.201601583

Reference yield: 80.0%

indole (120-72-9) + 1-nitro-4-phenylbut-1-ene (80922-14-1) → 3-(1'-nitromethyl-3-phenylpropyl)-1H-indole (1167436-57-8)

Guidance literature:

With Montmorillonite K₁₀; at 20 ℃; for 2h; Neat (no solvent);

DOI:10.1080/00397910802632555

Reference yield: 12.0%

indole (120-72-9) + 1-nitro-4-phenylbut-1-ene (80922-14-1) + benzaldehyde (100-52-7) → 3-(1'-nitromethyl-3-phenylpropyl)-1H-indole (1167436-57-8) + 3-(1H-indol-3-yl)-2-nitro-1,5-diphenylpentan-1-ol + 3-(1H-indol-3-yl)-2-nitro-1,5-diphenylpentan-1-ol (1054585-68-0)

Guidance literature:

With copper(I) trifluoromethanesulfonate benzene; 1,1,1,3',3',3'-hexafluoro-propanol; 2-{[(1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamino]methyl}-4,6-dibromophenol; In toluene; at 20 ℃; for 15h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1002/anie.200801373

upstream raw materials:

indole

1-nitro-4-phenylbut-1-ene

benzaldehyde

(E)-(4-nitrobut-3-enyl)benzene