6-chloro-4-(5,6-dichloro-1H-benzimidazol-2-yl)-2-(4-fluorophenyl)quinoline

Base Information

Chemical Name:6-chloro-4-(5,6-dichloro-1H-benzimidazol-2-yl)-2-(4-fluorophenyl)quinoline
CAS No.:1394063-76-3
Molecular Formula:C₂₂H₁₁Cl₃FN₃
Molecular Weight:442.707
Hs Code.:

Synonyms:6-chloro-4-(5,6-dichloro-1H-benzimidazol-2-yl)-2-(4-fluorophenyl)quinoline

Suppliers and Price of 6-chloro-4-(5,6-dichloro-1H-benzimidazol-2-yl)-2-(4-fluorophenyl)quinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-chloro-4-(5,6-dichloro-1H-benzimidazol-2-yl)-2-(4-fluorophenyl)quinoline

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Technology Process of 6-chloro-4-(5,6-dichloro-1H-benzimidazol-2-yl)-2-(4-fluorophenyl)quinoline

There total 4 articles about 6-chloro-4-(5,6-dichloro-1H-benzimidazol-2-yl)-2-(4-fluorophenyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 5348-42-5
4,5-Dichloro-1,2-phenylenediamine

: 897559-90-9
6-chloro-2-(4-fluorophenyl)quinoline-4-carboxylic acid

: 1394063-76-3
6-chloro-4-(5,6-dichloro-1H-benzimidazol-2-yl)-2-(4-fluorophenyl)quinoline

Guidance literature:: 4,5-Dichloro-1,2-phenylenediamine; 6-chloro-2-(4-fluorophenyl)quinoline-4-carboxylic acid; at 250 ℃; for 2h;

With sodium carbonate; In water;
DOI:10.1016/j.ejmech.2012.05.027

Reference yield:

: 106-47-8
4-chloro-aniline

: 1394063-76-3
6-chloro-4-(5,6-dichloro-1H-benzimidazol-2-yl)-2-(4-fluorophenyl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 1 h / Reflux

2: trifluoroacetic acid / ethanol / 12 h / Reflux

3: polyphosphoric acid / 2 h / 250 °C

With trifluoroacetic acid; In ethanol;
DOI:10.1016/j.ejmech.2012.05.027

Reference yield:

: 39769-10-3,103749-63-9
4-chloro-N-(4-fluorobenzylidene)aniline

: 1394063-76-3
6-chloro-4-(5,6-dichloro-1H-benzimidazol-2-yl)-2-(4-fluorophenyl)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / ethanol / 12 h / Reflux

2: polyphosphoric acid / 2 h / 250 °C

With trifluoroacetic acid; In ethanol;
DOI:10.1016/j.ejmech.2012.05.027