(S)-2-(1-biphenyl-4-yl-1-methylethyl)-5-oxo-pyrrolidine-1-carboxylic acid t-butyl ester

Base Information

Chemical Name:(S)-2-(1-biphenyl-4-yl-1-methylethyl)-5-oxo-pyrrolidine-1-carboxylic acid t-butyl ester
CAS No.:1383029-27-3
Molecular Formula:C₂₄H₂₉NO₃
Molecular Weight:379.499
Hs Code.:

Synonyms:(S)-2-(1-biphenyl-4-yl-1-methylethyl)-5-oxo-pyrrolidine-1-carboxylic acid t-butyl ester

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Chemical Property of (S)-2-(1-biphenyl-4-yl-1-methylethyl)-5-oxo-pyrrolidine-1-carboxylic acid t-butyl ester

Chemical Property:

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Technology Process of (S)-2-(1-biphenyl-4-yl-1-methylethyl)-5-oxo-pyrrolidine-1-carboxylic acid t-butyl ester

There total 12 articles about (S)-2-(1-biphenyl-4-yl-1-methylethyl)-5-oxo-pyrrolidine-1-carboxylic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383029-23-9
C₂₈H₃₅NO₆

: 1383029-27-3
(S)-2-(1-biphenyl-4-yl-1-methylethyl)-5-oxo-pyrrolidine-1-carboxylic acid t-butyl ester

Guidance literature:: In toluene; for 3h; Reflux;

Reference yield:

: 32454-16-3
2-(4-bromophenyl)-2-methyl-propionaldehyde

: 1383029-27-3
(S)-2-(1-biphenyl-4-yl-1-methylethyl)-5-oxo-pyrrolidine-1-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: ammonium carbonate / water / Reflux

2: sodium hydroxide / ethylene glycol / 38 h / 120 °C

3: triethylamine / dichloromethane / 0 °C / Reflux

4: sodium hydroxide / methanol / 4 h / 20 °C

5: lithium hydroxide / water / 60 h / 37 °C / pH 8.5

6: hydrogenchloride; water / Reflux

7: water; acetone / 2 h / 20 °C

8: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 8 h / 75 °C / Inert atmosphere

9: dmap; dicyclohexyl-carbodiimide / dichloromethane / -5 °C

10: sodium tetrahydroborate; acetic acid / dichloromethane / 3.5 h / -5 °C / Inert atmosphere

11: toluene / 3 h / Reflux

With hydrogenchloride; dmap; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; ammonium carbonate; potassium carbonate; acetic acid; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; lithium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; ethylene glycol; acetone; toluene;

Reference yield:

: 101184-73-0
2-(4-bromophenyl)-2-methylpropanenitrile

: 1383029-27-3
(S)-2-(1-biphenyl-4-yl-1-methylethyl)-5-oxo-pyrrolidine-1-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: diisobutylaluminium hydride / dichloromethane; mineral oil / -78 °C

1.2: 20 °C

2.1: ammonium carbonate / water / Reflux

3.1: sodium hydroxide / ethylene glycol / 38 h / 120 °C

4.1: triethylamine / dichloromethane / 0 °C / Reflux

5.1: sodium hydroxide / methanol / 4 h / 20 °C

6.1: lithium hydroxide / water / 60 h / 37 °C / pH 8.5

7.1: hydrogenchloride; water / Reflux

8.1: water; acetone / 2 h / 20 °C

9.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 8 h / 75 °C / Inert atmosphere

10.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / -5 °C

11.1: sodium tetrahydroborate; acetic acid / dichloromethane / 3.5 h / -5 °C / Inert atmosphere

12.1: toluene / 3 h / Reflux

With hydrogenchloride; dmap; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; ammonium carbonate; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; lithium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; ethylene glycol; acetone; toluene; mineral oil;