(1R,2R,3R,4R)-1,4-Bis(benzyloxy)-3-(hydroxymethyl)-2-<2-(p-phenylbenzoyloxy)ethyl>cyclopentan

Base Information

Chemical Name:(1R,2R,3R,4R)-1,4-Bis(benzyloxy)-3-(hydroxymethyl)-2-<2-(p-phenylbenzoyloxy)ethyl>cyclopentan
CAS No.:88365-34-8
Molecular Formula:C₃₅H₃₆O₅
Molecular Weight:536.668
Hs Code.:

Synonyms:(1R,2R,3R,4R)-1,4-Bis(benzyloxy)-3-(hydroxymethyl)-2-<2-(p-phenylbenzoyloxy)ethyl>cyclopentan

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Chemical Property of (1R,2R,3R,4R)-1,4-Bis(benzyloxy)-3-(hydroxymethyl)-2-<2-(p-phenylbenzoyloxy)ethyl>cyclopentan

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Technology Process of (1R,2R,3R,4R)-1,4-Bis(benzyloxy)-3-(hydroxymethyl)-2-<2-(p-phenylbenzoyloxy)ethyl>cyclopentan

There total 7 articles about (1R,2R,3R,4R)-1,4-Bis(benzyloxy)-3-(hydroxymethyl)-2-<2-(p-phenylbenzoyloxy)ethyl>cyclopentan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 14002-51-8
4-biphenyl-carboxylic acid chloride

: 88365-33-7
(1R,2R,3R,4R)-(+)-1,4-Bis(benzyloxy)-2-(2-hydroxyethyl)-3-(hydroxymethyl)cyclopentan

: 88365-34-8
(1R,2R,3R,4R)-1,4-Bis(benzyloxy)-3-(hydroxymethyl)-2-<2-(p-phenylbenzoyloxy)ethyl>cyclopentan

Guidance literature:: In pyridine; for 2.5h; Ambient temperature;
DOI:10.1002/jlac.198319831215

Reference yield:

: 100-39-0
benzyl bromide

: 88365-34-8
(1R,2R,3R,4R)-1,4-Bis(benzyloxy)-3-(hydroxymethyl)-2-<2-(p-phenylbenzoyloxy)ethyl>cyclopentan

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaH (80percent in oil) / 1) DMF, 0.5 h, -5 deg C, 2) 3 h, r. t.

2: 90 percent / Hg(II)-acetate, Hg(II)-oxide / H₂O; acetone / 1 h

3: 90 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 deg C to r. t.

4: 34 percent / pyridine / 2.5 h / Ambient temperature

With lithium aluminium tetrahydride; mercury(II) diacetate; sodium hydride; mercury(II) oxide; In tetrahydrofuran; pyridine; water; acetone;
DOI:10.1002/jlac.198319831215

Reference yield:

: 74552-31-1
(6R,7R)-(-)-7-Hydroxy-3-oxabicyclo<4.3.0>non-1-en-9-on

: 88365-34-8
(1R,2R,3R,4R)-1,4-Bis(benzyloxy)-3-(hydroxymethyl)-2-<2-(p-phenylbenzoyloxy)ethyl>cyclopentan

Guidance literature:: Multi-step reaction with 6 steps

1: 16 g / TEA / tetrahydrofuran / 5 h / Ambient temperature

2: 11.3 g / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 °C

3: 1) NaH (80percent in oil) / 1) DMF, 0.5 h, -5 deg C, 2) 3 h, r. t.

4: 90 percent / Hg(II)-acetate, Hg(II)-oxide / H₂O; acetone / 1 h

5: 90 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 deg C to r. t.

6: 34 percent / pyridine / 2.5 h / Ambient temperature

With lithium aluminium tetrahydride; TEA; mercury(II) diacetate; sodium hydride; mercury(II) oxide; In tetrahydrofuran; pyridine; water; acetone;
DOI:10.1002/jlac.198319831215