{(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester

Base Information

• Chemical Name: {(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester
• CAS No.: 936366-46-0
• Molecular Formula: C₂₁H₁₉ClF₂NO₃PS
• Molecular Weight: 469.876
• Mol file: 936366-46-0.mol

Synonyms:{(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester

Chemical Property of {(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester

There total 6 articles about {(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H5F2NO (936366-62-0) → {(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester (936366-46-0)

Guidance literature:

ethyl (5-chlorobenzo[b]thiophen-3-yl)methyl(methyl)phosphinate; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 0.75h;

C₉H₅F₂NO; In tetrahydrofuran; hexanes; at -78 - 20 ℃;

Reference yield:

4-(2-bromovinyl)-1,2-difluorobenzene (1206708-55-5) + [carbamoyl(5-chlorobenzo[b]thiophen-3-yl)methyl]-methylphosphinic acid ethyl ester (1206680-28-5) → {(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester (936366-46-0)

Guidance literature:

[carbamoyl(5-chlorobenzo[b]thiophen-3-yl)methyl]-methylphosphinic acid ethyl ester; With caesium carbonate; N,N`-dimethylethylenediamine; copper(l) iodide; In N,N-dimethyl acetamide; at 20 - 75 ℃; Inert atmosphere;

4-(2-bromovinyl)-1,2-difluorobenzene; In N,N-dimethyl acetamide; at 75 - 85 ℃; Product distribution / selectivity; Inert atmosphere;

Reference yield:

ethyl (5-chlorobenzo[b]thiophen-3-yl)methyl(methyl)phosphinate (862094-19-7) + C9H5F2NO (936366-62-0) → {(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester (936366-46-0)

Guidance literature:

ethyl (5-chlorobenzo[b]thiophen-3-yl)methyl(methyl)phosphinate; With n-butyllithium; In hexane; toluene; at -78 ℃; for 0.75h;

C₉H₅F₂NO; In hexane; toluene; at -78 ℃; for 0.5h; Further stages.;

DOI:10.1021/jm0700619

upstream raw materials:

ethyl (5-chlorobenzo[b]thiophen-3-yl)methyl(methyl)phosphinate

C₉H₅F₂NO

3-(bromomethyl)-5-chloro-1-benzothiophene

(E)-3-(3,4-difluorophenyl)acrylic acid

Downstream raw materials:

E-{(5-chloro-benzo[b]thiophen-3-yl)-[2-(3,4-difluoro-phenyl)-vinylcarbamoyl]-methyl}-methyl-phosphinic acid