(S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-propionyloxy}-4-methyl-pentanoic acid

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Chemical Name:(S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-propionyloxy}-4-methyl-pentanoic acid
CAS No.:178977-43-0
Molecular Formula:C₂₄H₃₅ClN₂O₈
Molecular Weight:515.004
Hs Code.:

Synonyms:(S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-propionyloxy}-4-methyl-pentanoic acid

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Chemical Property of (S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-propionyloxy}-4-methyl-pentanoic acid

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Technology Process of (S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-propionyloxy}-4-methyl-pentanoic acid

There total 5 articles about (S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-propionyloxy}-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 245125-86-4
benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(3-chloro-4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoate

: 178977-43-0
(S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-propionyloxy}-4-methyl-pentanoic acid

Guidance literature:: With hydrogen; palladium hydroxide - carbon; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1021/jo9907585

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 178977-43-0
(S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-propionyloxy}-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

2: 92.7 mg / 1-hydroxybenzotriazole; triethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / tetrahydrofuran; CH₂Cl₂ / 0 - 20 °C

3: hydrogen / Pd(OH)2 on carbon / ethyl acetate / 2 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; 1: Substitution / 2: Condensation / 3: Hydrogenolysis;
DOI:10.1021/jo9907585

Reference yield:

: 70601-62-6
(D)-N-acetyl-4-methoxy-phenylalanine

: 178977-43-0
(S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-propionyloxy}-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuryl chloride

3: 92.7 mg / 1-hydroxybenzotriazole; triethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / tetrahydrofuran; CH₂Cl₂ / 0 - 20 °C

4: hydrogen / Pd(OH)2 on carbon / ethyl acetate / 2 h / 20 °C

With sulfuryl dichloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; 1: Chlorination / 2: Substitution / 3: Condensation / 4: Hydrogenolysis;
DOI:10.1021/jo9907585