tert-butyl (5S,6R)-5-[(2S)-2-[3-[(2R)-2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),-7(E)-dienoate

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Chemical Name:tert-butyl (5S,6R)-5-[(2S)-2-[3-[(2R)-2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),-7(E)-dienoate
CAS No.:245125-91-1
Molecular Formula:C₄₃H₅₉ClN₂O₁₀
Molecular Weight:799.402
Hs Code.:

tert-butyl (5S,6R)-5-[(2S)-2-[3-[(2R)-2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),-7(E)-dienoate

Synonyms:tert-butyl (5S,6R)-5-[(2S)-2-[3-[(2R)-2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),-7(E)-dienoate

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Chemical Property of tert-butyl (5S,6R)-5-[(2S)-2-[3-[(2R)-2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),-7(E)-dienoate

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Technology Process of tert-butyl (5S,6R)-5-[(2S)-2-[3-[(2R)-2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),-7(E)-dienoate

There total 22 articles about tert-butyl (5S,6R)-5-[(2S)-2-[3-[(2R)-2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),-7(E)-dienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 178977-57-6
tert-butyl (5S,6R,2E,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoate

: 178977-43-0
(S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-propionyloxy}-4-methyl-pentanoic acid

: 245125-91-1
tert-butyl (5S,6R)-5-[(2S)-2-[3-[(2R)-2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),-7(E)-dienoate

Guidance literature:: With dmap; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jo9907585

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 245125-91-1
tert-butyl (5S,6R)-5-[(2S)-2-[3-[(2R)-2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),-7(E)-dienoate

Guidance literature:: Multi-step reaction with 4 steps

2: 92.7 mg / 1-hydroxybenzotriazole; triethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / tetrahydrofuran; CH₂Cl₂ / 0 - 20 °C

3: hydrogen / Pd(OH)2 on carbon / ethyl acetate / 2 h / 20 °C

4: 85 percent / 4-(dimethylamino)pyridine; 1,3-diisopropylcarbodiimide / CH₂Cl₂ / 18 h / 20 °C

With dmap; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropyl-carbodiimide; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; 1: Substitution / 2: Condensation / 3: Hydrogenolysis / 4: Esterification;
DOI:10.1021/jo9907585

Reference yield:

: 70601-62-6
(D)-N-acetyl-4-methoxy-phenylalanine

: 245125-91-1
tert-butyl (5S,6R)-5-[(2S)-2-[3-[(2R)-2-(tert-butoxycarbonylamino)-3-(3-chloro-4-methoxyphenyl)propionylamino]propionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),-7(E)-dienoate

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuryl chloride

3: 92.7 mg / 1-hydroxybenzotriazole; triethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / tetrahydrofuran; CH₂Cl₂ / 0 - 20 °C

4: hydrogen / Pd(OH)2 on carbon / ethyl acetate / 2 h / 20 °C

5: 85 percent / 4-(dimethylamino)pyridine; 1,3-diisopropylcarbodiimide / CH₂Cl₂ / 18 h / 20 °C

With dmap; sulfuryl dichloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropyl-carbodiimide; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; 1: Chlorination / 2: Substitution / 3: Condensation / 4: Hydrogenolysis / 5: Esterification;
DOI:10.1021/jo9907585