DIETHYL 2-[(4-METHYLPHENYL)METHYLENEMALONATE]

Base Information

• Chemical Name: DIETHYL 2-[(4-METHYLPHENYL)METHYLENEMALONATE]
• CAS No.: 14111-33-2
• Molecular Formula: C15H18 O4
• Molecular Weight: 262.306
• Hs Code.: 2917399090
• Mol file: 14111-33-2.mol

Synonyms:Malonicacid, (p-methylbenzylidene)-, diethyl ester (6CI,8CI); Propanedioic acid,[(4-methylphenyl)methylene]-, diethyl ester (9CI); Diethyl(4-methylbenzylidene)malonate; Diethyl (p-methylbenzylidene)malonate

Chemical Property of DIETHYL 2-[(4-METHYLPHENYL)METHYLENEMALONATE]

Chemical Property:

• Vapor Pressure: 0.000121mmHg at 25°C
• Melting Point: 46-67 °C
• Boiling Point: 335.2°Cat760mmHg
• Flash Point: 158.9°C
• PSA: 52.60000
• Density: 1.111g/cm³
• LogP: 2.50460

Purity/Quality:

98%min ^*data from raw suppliers

Diethyl 2-[(4-methylphenyl)methylene]malonate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIETHYL 2-[(4-METHYLPHENYL)METHYLENEMALONATE]

There total 12 articles about DIETHYL 2-[(4-METHYLPHENYL)METHYLENEMALONATE] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methyl-benzaldehyde (104-87-0) + diethyl malonate (105-53-3) → diethyl 2-(4-methylbenzylidene)malonate (14111-33-2)

Guidance literature:

With piperidine; In benzene; for 18h; Heating;

DOI:10.1021/jm9508853

Reference yield: 99.0%

2-(2-p-Tolyl-1λ4-naphtho[1,8-de][1,3]dithiin-1-ylidene)-malonic acid diethyl ester (172845-78-2) → diethyl 2-(4-methylbenzylidene)malonate (14111-33-2) + 1,8-naphthalenedisulfide (209-22-3)

Guidance literature:

In dichloromethane; Ambient temperature; Irradiation;

DOI:10.1016/0040-4039(95)01702-J

Reference yield: 99.0%

→ diethyl 2-(4-methylbenzylidene)malonate (14111-33-2)

Guidance literature:

upstream raw materials:

4-methyl-benzaldehyde

diethyl malonate

diethyl 2-(chloromethylene)malonate

toluene

Downstream raw materials:

diethyl 2-(4,4'-dimethylbenzhydryl)malonate

dibenzhydryl-malonic acid diethyl ester

diethyl 2-(2-cyano-3-(4-methoxyphenylamino)-3-oxo-1-p-tolylpropyl)malonate

C₃₁H₃₃NO₆

Refernces

• 1、 Bolt, Robert R. A.,Browne, Duncan L.,Howard, Joseph L.,Khan, Adam,Magri, Giuseppina,Morrill, Louis C.,Nicholson, William I.,Richards, Emma,Seastram, Alex C.. "Ball-Milling-Enabled Reactivity of Manganese Metal**". supporting information. p. 23128 - 23133. Retrieved 2021/09/20.
• 2、 Banerjee, Prabal,Maajid Taily, Irshad,Saha, Debarshi. "Electricity Driven 1,3-Oxohydroxylation of Donor-Acceptor Cyclopropanes: a Mild and Straightforward Access to β-Hydroxy Ketones". supporting information. p. 5053 - 5057. Retrieved 2021/09/30.