(2-{[(1S,4S,8R)-10-((2R,8S)-8-Benzyl-4-oxo-1,2,3,4,5,6,7,8-octahydro-quinoline-2-carbonyl)-6-oxo-3,10-diaza-tricyclo[6.2.1.0^2,7]undec-2⁽⁷⁾-ene-4-carbonyl]-amino}-ethyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (2-{[(1S,4S,8R)-10-((2R,8S)-8-Benzyl-4-oxo-1,2,3,4,5,6,7,8-octahydro-quinoline-2-carbonyl)-6-oxo-3,10-diaza-tricyclo[6.2.1.0^2,7]undec-2⁽⁷⁾-ene-4-carbonyl]-amino}-ethyl)-carbamic acid tert-butyl ester
• CAS No.: 177723-63-6
• Molecular Formula: C₃₄H₄₃N₅O₆
• Molecular Weight: 617.745

Synonyms:(2-{[(1S,4S,8R)-10-((2R,8S)-8-Benzyl-4-oxo-1,2,3,4,5,6,7,8-octahydro-quinoline-2-carbonyl)-6-oxo-3,10-diaza-tricyclo[6.2.1.0^2,7]undec-2⁽⁷⁾-ene-4-carbonyl]-amino}-ethyl)-carbamic acid tert-butyl ester

Chemical Property of (2-{[(1S,4S,8R)-10-((2R,8S)-8-Benzyl-4-oxo-1,2,3,4,5,6,7,8-octahydro-quinoline-2-carbonyl)-6-oxo-3,10-diaza-tricyclo[6.2.1.0^2,7]undec-2⁽⁷⁾-ene-4-carbonyl]-amino}-ethyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-{[(1S,4S,8R)-10-((2R,8S)-8-Benzyl-4-oxo-1,2,3,4,5,6,7,8-octahydro-quinoline-2-carbonyl)-6-oxo-3,10-diaza-tricyclo[6.2.1.0^2,7]undec-2⁽⁷⁾-ene-4-carbonyl]-amino}-ethyl)-carbamic acid tert-butyl ester

There total 11 articles about (2-{[(1S,4S,8R)-10-((2R,8S)-8-Benzyl-4-oxo-1,2,3,4,5,6,7,8-octahydro-quinoline-2-carbonyl)-6-oxo-3,10-diaza-tricyclo[6.2.1.0^2,7]undec-2⁽⁷⁾-ene-4-carbonyl]-amino}-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-BOC-1,2-diaminoethane (57260-73-8) → (2-{[(1S,4S,8R)-10-((2R,8S)-8-Benzyl-4-oxo-1,2,3,4,5,6,7,8-octahydro-quinoline-2-carbonyl)-6-oxo-3,10-diaza-tricyclo[6.2.1.02,7]undec-2(7)-ene-4-carbonyl]-amino}-ethyl)-carbamic acid tert-butyl ester (177723-63-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / EDC, HOBT, Et₃N / CH₂Cl₂ / 15 h / Ambient temperature

2: 50 percent / Pd/C / cyclohexene; methanol / 0.33 h / Heating

3: H₂ / Pd/C / methanol / 24 h / 760 Torr

4: 35 mg / EDC, HOBT, Et₃N / CH₂Cl₂ / 24 h

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; cyclohexene;

DOI:10.1021/jo9522771

Reference yield:

(-)-(1S,1'R)-2-(1'-Phenylethyl)-2-azabicyclo<2.2.1>hept-5-ene (149494-50-8) → (2-{[(1S,4S,8R)-10-((2R,8S)-8-Benzyl-4-oxo-1,2,3,4,5,6,7,8-octahydro-quinoline-2-carbonyl)-6-oxo-3,10-diaza-tricyclo[6.2.1.02,7]undec-2(7)-ene-4-carbonyl]-amino}-ethyl)-carbamic acid tert-butyl ester (177723-63-6)

Guidance literature:

Multi-step reaction with 9 steps

1: 1.) BH₃*THF, 2.) H₂O₂, NaOH / 1.) THF, rt, 1 h, 2.) THF, H₂O, rt, 45 min

2: oxalyl chloride, DMSO / CH₂Cl₂; diethyl ether

3: KHMDS / 1.) THF, -78 deg C, 30 min, 2.) 10 min

4: 1.) MeLi / 1.) THF, Et₂O, -10 deg C, 10 min, 2.) rt, 30 min

5: 398 mg / KOH / tetrahydrofuran; H₂O / 1 h / Ambient temperature

6: 71 percent / EDC, HOBT, Et₃N / CH₂Cl₂ / 15 h / Ambient temperature

7: 50 percent / Pd/C / cyclohexene; methanol / 0.33 h / Heating

8: H₂ / Pd/C / methanol / 24 h / 760 Torr

9: 35 mg / EDC, HOBT, Et₃N / CH₂Cl₂ / 24 h

With potassium hydroxide; sodium hydroxide; borane-THF; oxalyl dichloride; methyllithium; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; benzotriazol-1-ol; dimethyl sulfoxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; cyclohexene;

DOI:10.1021/jo9522771

Reference yield:

1-phenethyl-3-oxo-1-azabicyclo[2.2.1]heptane (177723-59-0) → (2-{[(1S,4S,8R)-10-((2R,8S)-8-Benzyl-4-oxo-1,2,3,4,5,6,7,8-octahydro-quinoline-2-carbonyl)-6-oxo-3,10-diaza-tricyclo[6.2.1.02,7]undec-2(7)-ene-4-carbonyl]-amino}-ethyl)-carbamic acid tert-butyl ester (177723-63-6)

Guidance literature:

Multi-step reaction with 7 steps

1: KHMDS / 1.) THF, -78 deg C, 30 min, 2.) 10 min

2: 1.) MeLi / 1.) THF, Et₂O, -10 deg C, 10 min, 2.) rt, 30 min

3: 398 mg / KOH / tetrahydrofuran; H₂O / 1 h / Ambient temperature

4: 71 percent / EDC, HOBT, Et₃N / CH₂Cl₂ / 15 h / Ambient temperature

5: 50 percent / Pd/C / cyclohexene; methanol / 0.33 h / Heating

6: H₂ / Pd/C / methanol / 24 h / 760 Torr

7: 35 mg / EDC, HOBT, Et₃N / CH₂Cl₂ / 24 h

With potassium hydroxide; methyllithium; hydrogen; potassium hexamethylsilazane; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; cyclohexene;

DOI:10.1021/jo9522771

upstream raw materials:

(2R,8S)-8-Benzyl-4-oxo-1,2,3,4,5,6,7,8-octahydro-quinoline-2-carboxylic acid

{2-[((1S,4S,8R)-6-Oxo-3,10-diaza-tricyclo[6.2.1.0^2,7]undec-2⁽⁷⁾-ene-4-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester

N-BOC-1,2-diaminoethane

(-)-(1S,1'R)-2-(1'-Phenylethyl)-2-azabicyclo<2.2.1>hept-5-ene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 177723-63-6 (2-{[(1S,4S,8R)-10-((2R,8S)-8-Benzyl-4-oxo-1,2,3,4,5,6,7,8-octahydro-quinoline-2-carbonyl)-6-oxo-3,10-diaza-tricyclo[6.2.1.0^2,7]undec-2⁽⁷⁾-ene-4-carbonyl]-amino}-ethyl)-carbamic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send