4-Chloro-8-fluoro-2-methylquinoline

Base Information

Chemical Name:4-Chloro-8-fluoro-2-methylquinoline
CAS No.:18615-59-3
Molecular Formula:C10H7ClFN
Molecular Weight:195.624
Hs Code.:2933499090
European Community (EC) Number:681-623-0
DSSTox Substance ID:DTXSID10488855
Wikidata:Q82331781
Mol file:18615-59-3.mol

Synonyms:4-Chloro-8-fluoro-2-methylquinoline;18615-59-3;4-Chloro-8-fluoro-2-methyl-quinoline;Quinoline,4-chloro-8-fluoro-2-methyl-;SCHEMBL3051550;DTXSID10488855;PKLIYBDVJXLAHP-UHFFFAOYSA-N;2,2,3,3-Tetramethyl-4-pentenal;MFCD00272335;AKOS002663687;AB05610;CCG-321767;AS-37242;4-chloranyl-8-fluoranyl-2-methyl-quinoline;FT-0618147;?4-CHLORO-8-FLUORO-2-METHYLQUINOLINE;EN300-110479;4-Chloro-8-fluoro-2-methylquinoline, AldrichCPR;A813012;J-650144;Z234898817

Suppliers and Price of 4-Chloro-8-fluoro-2-methylquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloro-8-fluoro-2-methylquinoline
250mg
$ 65.00

TRC
4-Chloro-8-fluoro-2-methylquinoline
1g
$ 145.00

SynQuest Laboratories
4-Chloro-8-fluoro-2-methylquinoline
5 g
$ 536.00

SynQuest Laboratories
4-Chloro-8-fluoro-2-methylquinoline
1 g
$ 208.00

Sigma-Aldrich
4-Chloro-8-fluoro-2-methylquinoline Aldrich
1g
$ 144.00

Matrix Scientific
4-Chloro-8-fluoro-2-methylquinoline 98%
10g
$ 1355.00

Matrix Scientific
4-Chloro-8-fluoro-2-methylquinoline 98%
5g
$ 908.00

Matrix Scientific
4-Chloro-8-fluoro-2-methylquinoline 98%
1g
$ 341.00

Crysdot
4-Chloro-8-fluoro-2-methylquinoline 98%
10g
$ 678.00

Crysdot
4-Chloro-8-fluoro-2-methylquinoline 98%
5g
$ 422.00

Total 29 raw suppliers

Chemical Property of 4-Chloro-8-fluoro-2-methylquinoline

Chemical Property:

Vapor Pressure:0.012mmHg at 25°C
Refractive Index:1.612
Boiling Point:269.859 °C at 760 mmHg
Flash Point:117.007 °C
PSA：12.89000
Density:1.311 g/cm³
LogP:3.33570
Storage Temp.:2-8°C
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:195.0251051
Heavy Atom Count:13
Complexity:188

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-8-fluoro-2-methylquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-41
Safety Statements: 26-39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C2C=CC=C(C2=N1)F)Cl

Technology Process of 4-Chloro-8-fluoro-2-methylquinoline

There total 4 articles about 4-Chloro-8-fluoro-2-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 348-54-9
2-Fluoroaniline

: 18615-59-3
4-chloro-8-fluoro-quinaldine

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 7 h / 40 °C

2: diphenylether / 0.5 h / Reflux

3: trichlorophosphate / 3 h / Reflux

With trichlorophosphate; In methanol; diphenylether;
DOI:10.1007/s00044-011-9854-3

Reference yield:

: C₁₂H₁₄FNO₂

: 18615-59-3
4-chloro-8-fluoro-quinaldine

Guidance literature:: Multi-step reaction with 2 steps

1: diphenylether / 0.5 h / Reflux

2: trichlorophosphate / 3 h / Reflux

With trichlorophosphate; In diphenylether;
DOI:10.1007/s00044-011-9854-3