5288-22-2 Usage
Uses
Used in Pharmaceutical Industry:
8-FLUORO-2-METHYL-4-QUINOLINOL is used as an antibiotic for the treatment of various bacterial infections. It is particularly effective for infections affecting the urinary tract and respiratory system due to its ability to inhibit bacterial DNA gyrase and topoisomerase IV, which are essential for bacterial DNA replication.
Used in Treatment of Gram-Positive and Gram-Negative Bacterial Infections:
8-FLUORO-2-METHYL-4-QUINOLINOL is used as a broad-spectrum antibiotic for combating a wide range of gram-positive and gram-negative bacteria, including antibiotic-resistant strains. Its high bioavailability contributes to its effectiveness in treating these infections.
Used in Regions with Limited Treatment Options:
8-FLUORO-2-METHYL-4-QUINOLINOL is used as a therapeutic option in specific regions where other treatment options for certain bacterial infections may be limited, despite concerns about potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 5288-22-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,2,8 and 8 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 5288-22:
(6*5)+(5*2)+(4*8)+(3*8)+(2*2)+(1*2)=102
102 % 10 = 2
So 5288-22-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H8FNO/c1-6-5-9(13)7-3-2-4-8(11)10(7)12-6/h2-5H,1H3,(H,12,13)
5288-22-2Relevant academic research and scientific papers
N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors
Luo, Wei,Liu, Yang,Wang, Jian,Guo, Chun,Lu, Wei-Qiang,Cui, Kun-Qiang
, p. 3073 - 3079,7 (2020/08/20)
A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.
Studies on haloquinolines : Part I - Synthesis and characterisation of substituted haloquinolines
Rao, D. Mohan,Giridhar,Reddy,Chandra Mouli
, p. 29 - 32 (2007/10/03)
Condensation reaction of halogenated anilines with ethyl acetoacetate affords quinoline 1,2,3. The compound 1 is coupled with benzenediazonium chloride and then reduced to furnish 3-amino- quinoline 5 which undergoes cyclisation with carbon disulphide to
