5288-22-2 Usage
General Description
8-FLUORO-2-METHYL-4-QUINOLINOL, also known as lomefloxacin, is a synthetic antibiotic belonging to the fluoroquinolone class. It was developed for the treatment of various bacterial infections, particularly those affecting the urinary tract and respiratory system. Lomefloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, ultimately interfering with DNA replication and leading to bacterial cell death. Its broad spectrum of activity and high bioavailability make it effective against a wide range of gram-positive and gram-negative bacteria, including strains that are resistant to other antibiotics. However, its use has been limited due to concerns about potential side effects, including tendon rupture and phototoxicity. Despite these limitations, lomefloxacin continues to be used in some regions for specific infections where other treatment options are limited.
Check Digit Verification of cas no
The CAS Registry Mumber 5288-22-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,2,8 and 8 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 5288-22:
(6*5)+(5*2)+(4*8)+(3*8)+(2*2)+(1*2)=102
102 % 10 = 2
So 5288-22-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H8FNO/c1-6-5-9(13)7-3-2-4-8(11)10(7)12-6/h2-5H,1H3,(H,12,13)
5288-22-2Relevant articles and documents
N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors
Luo, Wei,Liu, Yang,Wang, Jian,Guo, Chun,Lu, Wei-Qiang,Cui, Kun-Qiang
, p. 3073 - 3079,7 (2020/08/20)
A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.