Ethyl 1-Boc-3-piperidinecarboxylate

Base Information

• Chemical Name: Ethyl 1-Boc-3-piperidinecarboxylate
• CAS No.: 130250-54-3
• Molecular Formula: C₁₃H₂₃NO₄
• Molecular Weight: 257.33
• Hs Code.: 29333990
• Mol file: 130250-54-3.mol

Synonyms:1-(tert-Butoxycarbonyl)-3-(ethoxycarbonyl)piperidine;1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid ethyl ester;3-Ethyl 1-(1,1-dimethylethyl)1,3-piperidinedicarboxylate;Ethyl1-tert-butoxycarbonyl-3-piperidinecarboxylate;N-Boc-piperidine-3-carboxylic acid ethyl ester;1,3-Piperidinedicarboxylicacid, 1-(1,1-dimethylethyl) 3-ethyl ester;

Chemical Property of Ethyl 1-Boc-3-piperidinecarboxylate

Chemical Property:

• Appearance/Colour: white crystalline power
• Vapor Pressure: 0.000254mmHg at 25°C
• Melting Point: 31-35℃
• Refractive Index: 1.473
• Boiling Point: 323.9 °C at 760 mmHg
• PKA: -2.40±0.40(Predicted)
• Flash Point: 149.7 °C
• PSA: 55.84000
• Density: 1.077 g/cm³
• LogP: 2.13450
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Moisture & Light Sensitive

Purity/Quality:

98% ^*data from raw suppliers

Ethyl1-Boc-3-piperidinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36-43-52
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reactant for synthesis of:GABAA receptor agonistsPiperidine derivativesSelective TACE inhibitorsHDL-elevating agentsα-Sulfonyl hydroxamic acid derivativeschemicals in the Iboga-alkaloid family Reactant for synthesis of:? ;GABAA receptor agonists1? ;Piperidine derivatives2? ;Selective TACE inhibitors3? ;HDL-elevating agents4? ;α-Sulfonyl hydroxamic acid derivatives5? ;chemicals in the Iboga-alkaloid family6

Technology Process of Ethyl 1-Boc-3-piperidinecarboxylate

There total 5 articles about Ethyl 1-Boc-3-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + Ethyl nipecotate (71962-74-8) → ethyl N-(t-butyloxycarbonyl)nipecotate (148672-74-6,130250-54-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + ethyl piperidine-3-carboxylate hydrochloride (4842-86-8,37675-19-7) → ethyl N-(t-butyloxycarbonyl)nipecotate (148672-74-6,130250-54-3)

Guidance literature:

ethyl piperidine-3-carboxylate hydrochloride; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;

di-tert-butyl dicarbonate; In dichloromethane; for 16h;

Reference yield: 80.0%

→ ethyl N-(t-butyloxycarbonyl)nipecotate (148672-74-6,130250-54-3)

Guidance literature:

upstream raw materials:

di-tert-butyl dicarbonate

Ethyl nipecotate

ethyl piperidine-3-carboxylate hydrochloride

Downstream raw materials:

tert-butyl 3-carbamoylpiperidine-1-carboxylate

N-(tert-butyloxycarbonyl)nipecotic acid

3-pyridin-2-ylmethyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

1-tert-butyl 3-ethyl 3-methyl piperidine-1,3,3-tricarboxylate