5-[(tert-butoxycarbonyl)piperidin-3-yl]-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol

Base Information

Chemical Name:5-[(tert-butoxycarbonyl)piperidin-3-yl]-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol
CAS No.:934270-60-7
Molecular Formula:C₂₁H₂₅ClN₆O₃
Molecular Weight:444.921
Hs Code.:

Synonyms:5-[(tert-butoxycarbonyl)piperidin-3-yl]-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol

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Chemical Property of 5-[(tert-butoxycarbonyl)piperidin-3-yl]-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol

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Technology Process of 5-[(tert-butoxycarbonyl)piperidin-3-yl]-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol

There total 4 articles about 5-[(tert-butoxycarbonyl)piperidin-3-yl]-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 63777-70-8
2-chlorobenzylazide

: 148672-74-6,130250-54-3
ethyl N-(t-butyloxycarbonyl)nipecotate

: 107-91-5
cyanoacetic acid amide

: 934270-60-7
5-[(tert-butoxycarbonyl)piperidin-3-yl]-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol

Guidance literature:: 2-chlorobenzylazide; cyanoacetic acid amide; With sodium isopropylate; In isopropyl alcohol; for 2h; Heating;

ethyl N-(t-butyloxycarbonyl)nipecotate; In isopropyl alcohol; for 20h; Heating;
DOI:10.1007/s10593-006-0078-2

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 934270-60-7
5-[(tert-butoxycarbonyl)piperidin-3-yl]-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 78 percent / CH₂Cl₂ / 1 h

2.1: i-PrONa / propan-2-ol / 2 h / Heating

2.2: 45 percent / propan-2-ol / 20 h / Heating

With sodium isopropylate; In dichloromethane; isopropyl alcohol;
DOI:10.1007/s10593-006-0078-2

Reference yield:

: 611-19-8
1-chloro-2-(chloromethyl)benzene

: 934270-60-7
5-[(tert-butoxycarbonyl)piperidin-3-yl]-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / NaN₃ / acetonitrile / 2 h / Heating

2.1: i-PrONa / propan-2-ol / 2 h / Heating

2.2: 45 percent / propan-2-ol / 20 h / Heating

With sodium azide; sodium isopropylate; In isopropyl alcohol; acetonitrile;
DOI:10.1007/s10593-006-0078-2