(R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester

Base Information

• Chemical Name: (R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester
• CAS No.: 78037-12-4
• Molecular Formula: C₂₈H₂₄N₂O₄
• Molecular Weight: 452.51
• Mol file: 78037-12-4.mol

Synonyms:(R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester

Chemical Property of (R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester

There total 8 articles about (R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C28H26N2O5S (51415-31-7) → (R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester (78037-12-4,68107-98-2)

Guidance literature:

With triphenylphosphine; squaric acid; In N,N-dimethyl acetamide; toluene; Reflux;

DOI:10.3987/COM-12-12611

Reference yield: 84.0%

(2S,4S,6R)-6-Benzoylamino-3,3-dimethyl-4,7-dioxo-4λ4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester (51415-31-7,68000-29-3,69780-18-3,73037-40-8,77943-73-8,77943-74-9) → (R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester (78037-12-4,68107-98-2)

Guidance literature:

With triphenylphosphine; squaric acid; In N,N-dimethyl acetamide; toluene; for 1.5h; Heating;

DOI:10.1016/S0040-4039(01)81835-9

Reference yield: 46.0%

(2S,4S,6R)-6-Benzoylamino-3,3-dimethyl-4,7-dioxo-4λ4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester (51415-31-7,68000-29-3,69780-18-3,73037-40-8,77943-73-8,77943-74-9) + benzoic acid (65-85-0,8013-63-6) → Benzoic acid (S)-1-((R)-1-benzhydryloxycarbonyl-2-methyl-allyl)-3-benzoylamino-4-oxo-azetidin-2-yl ester + (R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester (78037-12-4,68107-98-2)

Guidance literature:

With phosphorous acid trimethyl ester; In benzene; for 15h; Heating;

DOI:10.1016/S0040-4039(01)81835-9

upstream raw materials:

(2S,4S,6R)-6-Benzoylamino-3,3-dimethyl-4,7-dioxo-4λ⁴-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester

benzoic acid

Trimethylacetic acid

6-Aminopenicillanic Acid

Downstream raw materials:

C₂₃H₂₈N₂O₆

C₂₂H₂₂N₂O₇

C₂₂H₂₂N₂O₇

C₂₂H₂₃N₃O₆