(R)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile

Base Information

• Chemical Name: (R)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile
• CAS No.: 944468-39-7
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.186
• Mol file: 944468-39-7.mol

Synonyms:(R)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile

Chemical Property of (R)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile

There total 2 articles about (R)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-(4-cyanophenyl)-3-oxopropanenitrile (71292-11-0) → (R)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile (944468-39-7)

Guidance literature:

With D-glucose; D-glucose dehydrogenase; NADPH; Candida magnoliae carbonyl reductase; In phosphate buffer; dimethyl sulfoxide; at 20 ℃; for 72h; pH=7.0;

DOI:10.1021/ol070962b

Reference yield:

3-(4-cyanophenyl)-3-oxopropanenitrile (71292-11-0) → (R)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile (944468-39-7) + (S)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile (1107616-67-0)

Guidance literature:

With formic acid; {Cp*Ir[(R,R)-C₆F₅SO₂DPEN](H₂O)}(SO₄); In water; at 20 ℃; for 24h; pH=3.5; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol1008894

Reference yield: 90.0%

(R)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile (944468-39-7) → (R)-3-(4'-cyanophenyl)-3-hydroxypropanoic acid

Guidance literature:

With Bradyrhizobium japonicum USDA₁₁₀ nitrilase; In phosphate buffer; at 30 ℃; for 24h; pH=7.2;

DOI:10.1021/ol070962b

upstream raw materials:

3-(4-cyanophenyl)-3-oxopropanenitrile

Refernces

• 1、 -. "CHIRAL IRIDIUM AQUA COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE HYDROXY COMPOUND USING THE SAME". Page/Page column 45. . Retrieved 2011/05/05.