(S)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile

Base Information

• Chemical Name: (S)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile
• CAS No.: 1107616-67-0
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.186
• Mol file: 1107616-67-0.mol

Synonyms:(S)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile

Chemical Property of (S)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile

There total 2 articles about (S)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-(4-cyanophenyl)-3-oxopropanenitrile (71292-11-0) → (S)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile (1107616-67-0)

Guidance literature:

With D-glucose; D-glucose dehydrogenase; alcohol dehydrogenase YMR₂₂₆c from Saccharomyces cerevisiae; NADPH; In dimethyl sulfoxide; at 20 ℃; for 36h; pH=7.0; optical yield given as %ee; enantioselective reaction; potassium phosphate buffer; Enzymatic reaction;

DOI:10.1021/jo802495f

Reference yield:

3-(4-cyanophenyl)-3-oxopropanenitrile (71292-11-0) → (R)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile (944468-39-7) + (S)-3-(4'-cyanophenyl)-3-hydroxypropanenitrile (1107616-67-0)

Guidance literature:

With formic acid; {Cp*Ir[(R,R)-C₆F₅SO₂DPEN](H₂O)}(SO₄); In water; at 20 ℃; for 24h; pH=3.5; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol1008894

upstream raw materials:

3-(4-cyanophenyl)-3-oxopropanenitrile

Refernces

• 1、 Ankati, Haribabu,Zhu, Dunming,Yang, Yan,Biehl, Edward R.,Hua, Ling. "Asymmetric synthesis of both antipodes of β-hydroxy nitriles and β-Hydroxy carboxylic acids via enzymatic reduction or sequential reduction/hydrolysis". supporting information; experimental part. p. 1658 - 1662. Retrieved 2009/08/08.