(R)-tert-butyl 2,3-dihydro-2-(4-fluorophenylmethyl)-1H-indole-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 2,3-dihydro-2-(4-fluorophenylmethyl)-1H-indole-1-carboxylate
CAS No.:1318240-18-4
Molecular Formula:C₂₀H₂₂FNO₂
Molecular Weight:327.399
Hs Code.:

Synonyms:(R)-tert-butyl 2,3-dihydro-2-(4-fluorophenylmethyl)-1H-indole-1-carboxylate

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Chemical Property of (R)-tert-butyl 2,3-dihydro-2-(4-fluorophenylmethyl)-1H-indole-1-carboxylate

Chemical Property:

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Technology Process of (R)-tert-butyl 2,3-dihydro-2-(4-fluorophenylmethyl)-1H-indole-1-carboxylate

There total 3 articles about (R)-tert-butyl 2,3-dihydro-2-(4-fluorophenylmethyl)-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1318240-17-3
(S)-tert-butyl 2,3-dihydro-2-(iodomethyl)-1H-indole-1-carboxylate

: 352-13-6
4-flourophenylmagnesium bromide

: 1318240-18-4
(R)-tert-butyl 2,3-dihydro-2-(4-fluorophenylmethyl)-1H-indole-1-carboxylate

Guidance literature:: With bis(triphenylphosphine)dichlorocobalt(II); N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at 25 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1002/adsc.201100220

Reference yield:

: 144069-67-0,133851-52-2
(S)-N-tert-butoxycarbonylindoline-2-carboxylic acid

: 1318240-18-4
(R)-tert-butyl 2,3-dihydro-2-(4-fluorophenylmethyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrafluoroboric acid-diethyl ether complex / tetrahydrofuran / 12 h / 0 - 20 °C

2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 12 h / 0 - 20 °C

3: bis(triphenylphosphine)dichlorocobalt(II); N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.67 h / 25 °C / Inert atmosphere

With 1H-imidazole; bis(triphenylphosphine)dichlorocobalt(II); tetrafluoroboric acid-diethyl ether complex; N,N,N,N,-tetramethylethylenediamine; iodine; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/adsc.201100220

Reference yield:

: 197460-25-6
(S)-tert-butyl 2-(hydroxymethyl)indoline-1-carboxylate

: 1318240-18-4
(R)-tert-butyl 2,3-dihydro-2-(4-fluorophenylmethyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 12 h / 0 - 20 °C

2: bis(triphenylphosphine)dichlorocobalt(II); N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.67 h / 25 °C / Inert atmosphere

With 1H-imidazole; bis(triphenylphosphine)dichlorocobalt(II); N,N,N,N,-tetramethylethylenediamine; iodine; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/adsc.201100220