methyl 2-carbomethoxy-3-hydroxy-4-phenyl-4-oxo-butanoate dimethyl ketal

Base Information

• Chemical Name: methyl 2-carbomethoxy-3-hydroxy-4-phenyl-4-oxo-butanoate dimethyl ketal
• CAS No.: 104504-76-9
• Molecular Formula: C₁₅H₂₀O₇
• Molecular Weight: 312.32
• Mol file: 104504-76-9.mol

Synonyms:methyl 2-carbomethoxy-3-hydroxy-4-phenyl-4-oxo-butanoate dimethyl ketal

Chemical Property of methyl 2-carbomethoxy-3-hydroxy-4-phenyl-4-oxo-butanoate dimethyl ketal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-carbomethoxy-3-hydroxy-4-phenyl-4-oxo-butanoate dimethyl ketal

There total 2 articles about methyl 2-carbomethoxy-3-hydroxy-4-phenyl-4-oxo-butanoate dimethyl ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

phenylglyoxal dimethylacetal (19159-39-8) + malonic acid dimethyl ester (108-59-8) → methyl 2-carbomethoxy-3-hydroxy-4-phenyl-4-oxo-butanoate dimethyl ketal (104504-76-9)

Guidance literature:

With piperidine; In 1,4-dioxane; for 96h; Ambient temperature;

Reference yield:

2,2-dichloroacetophenone (2648-61-5) → methyl 2-carbomethoxy-3-hydroxy-4-phenyl-4-oxo-butanoate dimethyl ketal (104504-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / MeONa / Ambient temperature

2: 88 percent / piperidine / dioxane / 96 h / Ambient temperature

With piperidine; sodium methylate; In 1,4-dioxane;

Reference yield: 56.0%

methyl 2-carbomethoxy-3-hydroxy-4-phenyl-4-oxo-butanoate dimethyl ketal (104504-76-9) → methyl 2-carbomethoxy-4-phenyl-4-oxo-butenoate dimethyl ketal (104504-77-0)

Guidance literature:

With thionyl chloride; In pyridine; at -10 ℃; for 3h; 2.) -10 deg C --> room temp., 1 h;

upstream raw materials:

phenylglyoxal dimethylacetal

malonic acid dimethyl ester

2,2-dichloroacetophenone

Downstream raw materials:

methyl 2-carbomethoxy-4-phenyl-4-oxo-butenoate dimethyl ketal

3-benzoyl-1-benzyl-2,2-dicarbomethoxy-aziridine

3-benzoyldimethylketal-1-benzyl-2,2-dicarbomethoxy-aziridine

5-benzoyldimethylketal-1-benzyl-4,4-dicarbomethoxy-1,2,3-triazoline