7-benzyl-4-chloro-2-(3-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine

Base Information

Chemical Name:7-benzyl-4-chloro-2-(3-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine
CAS No.:1065113-65-6
Molecular Formula:C₂₂H₂₁Cl₂N₃
Molecular Weight:398.335
Hs Code.:

Synonyms:7-benzyl-4-chloro-2-(3-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine

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Chemical Property of 7-benzyl-4-chloro-2-(3-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine

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Technology Process of 7-benzyl-4-chloro-2-(3-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine

There total 4 articles about 7-benzyl-4-chloro-2-(3-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.7%

: 1065113-64-5
7-benzyl-2-(3-chlorobenzyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one

: 1065113-65-6
7-benzyl-4-chloro-2-(3-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine

Guidance literature:: With tetraethylammonium chloride; trichlorophosphate; In propiononitrile; at 100 ℃; for 17h;

Reference yield:

: 19673-12-2
1-benzyl-5-oxo-azepane-4-carboxylic acid ethyl ester

: 1065113-65-6
7-benzyl-4-chloro-2-(3-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium ethanolate / ethanol / 18 h / Reflux

2: tetraethylammonium chloride; trichlorophosphate / propiononitrile / 18 h / 100 °C

With tetraethylammonium chloride; sodium ethanolate; trichlorophosphate; In ethanol; propiononitrile;
DOI:10.1016/j.bmcl.2010.11.120

Reference yield:

: 6487-96-3
3-Chlorophenylacetamidine hydrochloride

: 1065113-65-6
7-benzyl-4-chloro-2-(3-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium ethanolate / ethanol / 18 h / Reflux

2: tetraethylammonium chloride; trichlorophosphate / propiononitrile / 18 h / 100 °C

With tetraethylammonium chloride; sodium ethanolate; trichlorophosphate; In ethanol; propiononitrile;
DOI:10.1016/j.bmcl.2010.11.120