6-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidine

Base Information

• Chemical Name: 6-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidine
• CAS No.: 1062368-44-8
• Molecular Formula: C₁₉H₂₂N₄O
• Molecular Weight: 322.41
• Mol file: 1062368-44-8.mol

Synonyms:6-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidine

Chemical Property of 6-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 6-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidine

There total 1 articles about 6-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[2-(4-bromophenoxy)ethyl]piperidine (836-58-8) + 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine (1416437-27-8) → 6-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidine (1062368-44-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 105 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.bmcl.2018.09.006

Reference yield:

6-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidine (1062368-44-8) → 3-bromo-6-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidine (945376-96-5)

Guidance literature:

With N-Bromosuccinimide; In tetrahydrofuran; at 0 ℃; for 0.166667h;

DOI:10.1016/j.bmcl.2018.09.006

Reference yield:

6-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidine (1062368-44-8) → C29H29N5O3S

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / tetrahydrofuran / 0.17 h / 0 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 1 h / 105 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; water; 2: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2018.09.006

upstream raw materials:

1-[2-(4-bromophenoxy)ethyl]piperidine

6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine

Downstream raw materials:

3-bromo-6-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidine