N-[9-(2-{[2-(tert-butylamino)-2-oxoethyl](2-{2-[2-(2-carboxy-ethoxy)ethoxy]ethoxy}ethyl)carbamoyl}phenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium chloride

Base Information

• Chemical Name: N-[9-(2-{[2-(tert-butylamino)-2-oxoethyl](2-{2-[2-(2-carboxy-ethoxy)ethoxy]ethoxy}ethyl)carbamoyl}phenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium chloride
• CAS No.: 1356146-26-3
• Molecular Formula: C₄₃H₅₉N₄O₈*Cl
• Molecular Weight: 795.416
• Mol file: 1356146-26-3.mol

Synonyms:N-[9-(2-{[2-(tert-butylamino)-2-oxoethyl](2-{2-[2-(2-carboxy-ethoxy)ethoxy]ethoxy}ethyl)carbamoyl}phenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium chloride

Chemical Property of N-[9-(2-{[2-(tert-butylamino)-2-oxoethyl](2-{2-[2-(2-carboxy-ethoxy)ethoxy]ethoxy}ethyl)carbamoyl}phenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[9-(2-{[2-(tert-butylamino)-2-oxoethyl](2-{2-[2-(2-carboxy-ethoxy)ethoxy]ethoxy}ethyl)carbamoyl}phenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium chloride

There total 3 articles about N-[9-(2-{[2-(tert-butylamino)-2-oxoethyl](2-{2-[2-(2-carboxy-ethoxy)ethoxy]ethoxy}ethyl)carbamoyl}phenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-[9-(2-([2-(tert-butylamino)-2-oxoethyl](14,14-dimethyl-12-oxo-3,6,9,13-tetraoxapentadec-1-yl)carbamoyl) phenyl)-6-(diethyl-amino)-3H-xanthen-3-ylidene]-N-ethylethanaminium chloride (1356146-21-8) → N-[9-(2-{[2-(tert-butylamino)-2-oxoethyl](2-{2-[2-(2-carboxy-ethoxy)ethoxy]ethoxy}ethyl)carbamoyl}phenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium chloride (1356146-26-3)

Guidance literature:

With phosphoric acid; In toluene; at 20 ℃; for 3h;

DOI:10.1039/c1ob06581e

Reference yield:

tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate (252881-74-6,872340-65-3) → N-[9-(2-{[2-(tert-butylamino)-2-oxoethyl](2-{2-[2-(2-carboxy-ethoxy)ethoxy]ethoxy}ethyl)carbamoyl}phenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium chloride (1356146-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 1 h / 100 °C / Microwave irradiation

2: phosphoric acid / toluene / 3 h / 20 °C

With phosphoric acid; In methanol; toluene; 1: Ugi condensation;

DOI:10.1039/c1ob06581e

Reference yield:

rhodamine B (81-88-9) → N-[9-(2-{[2-(tert-butylamino)-2-oxoethyl](2-{2-[2-(2-carboxy-ethoxy)ethoxy]ethoxy}ethyl)carbamoyl}phenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium chloride (1356146-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 1 h / 100 °C / Microwave irradiation

2: phosphoric acid / toluene / 3 h / 20 °C

With phosphoric acid; In methanol; toluene; 1: Ugi condensation;

DOI:10.1039/c1ob06581e

upstream raw materials:

tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate

N-[9-(2-([2-(tert-butylamino)-2-oxoethyl](14,14-dimethyl-12-oxo-3,6,9,13-tetraoxapentadec-1-yl)carbamoyl) phenyl)-6-(diethyl-amino)-3H-xanthen-3-ylidene]-N-ethylethanaminium chloride

rhodamine B

Downstream raw materials:

N-(9-[2-([2-(tert-butylamino)-2-oxoethyl](2-[2-(2-( 3-[(2,5-dioxopyrrolidin-1-yl)oxy]-3-oxopropxy)ethoxy)ethoxy]ethyl)carbamoyl)phenyl]-6-(diethylamino)-3H-xanthen-3-ylidene)-N-ethyl-ethanaminium chloride