Technology Process of C20H22F3NO5S2
There total 12 articles about C20H22F3NO5S2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C19H21NO3S;
With
L-Selectride;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
N,N-phenylbistrifluoromethane-sulfonimide;
In
tetrahydrofuran;
at -78 - 23 ℃;
DOI:10.1021/ol051184v
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: P2O5 / CH2Cl2 / 48 h / 23 °C
2.1: DIBAL-H / toluene; hexane / 0.33 h / 0 °C
3.1: 0.188 g / IBX / dimethylsulfoxide / 4 h / 23 °C
4.1: 94 percent / mCPBA / CH2Cl2 / 1 h / 0 °C
5.1: Et3N; molecular sieves 3 Angstroem / methanol / 12 h / 23 °C
6.1: 0.38 g / NaBH4 / methanol / 0.5 h
7.1: 77 percent / Br2; AcOH / H2O; methanol / 2.5 h / 0 °C
8.1: 70 percent / toluene / 15 h / 120 °C
9.1: L-Selectride / tetrahydrofuran / 1 h / -78 °C
9.2: 72 percent / tetrahydrofuran / -78 - 23 °C
With
sodium tetrahydroborate; 3 A molecular sieve; bromine; phosphorus pentoxide; L-Selectride; diisobutylaluminium hydride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1021/ol051184v
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 94 percent / mCPBA / CH2Cl2 / 1 h / 0 °C
2.1: Et3N; molecular sieves 3 Angstroem / methanol / 12 h / 23 °C
3.1: 0.38 g / NaBH4 / methanol / 0.5 h
4.1: 77 percent / Br2; AcOH / H2O; methanol / 2.5 h / 0 °C
5.1: 70 percent / toluene / 15 h / 120 °C
6.1: L-Selectride / tetrahydrofuran / 1 h / -78 °C
6.2: 72 percent / tetrahydrofuran / -78 - 23 °C
With
sodium tetrahydroborate; 3 A molecular sieve; bromine; L-Selectride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1021/ol051184v
