PALMITOYLISOPROPYLAMIDE

Base Information

• Chemical Name: PALMITOYLISOPROPYLAMIDE
• CAS No.: 189939-61-5
• Molecular Formula: C₁₉H₃₉NO
• Molecular Weight: 297.525
• Mol file: 189939-61-5.mol

Synonyms:PALMITOYLISOPROPYLAMIDE;PALMITOYLNISOPROPYLAMIDE;NISOPROPYLHEXADECANAMIDE

Chemical Property of PALMITOYLISOPROPYLAMIDE

Chemical Property:

• Vapor Pressure: 2.9E-05mmHg at 25°C
• Boiling Point: 356.5°C at 760 mmHg
• Flash Point: 223.7°C
• PSA: 29.10000
• Density: 0.853g/cm³
• LogP: 6.38320
• Storage Temp.: Store at RT
• Solubility.: DMSO, Ethanol

Purity/Quality:

99% ^*data from raw suppliers

Palmitoylisopropylamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An inhibitor of fatty acid amide hydrolase (FAAH). pIC50=4.89 for inhibition of [3H]-anandamide metabolism. Displays little binding to CB1 and CB2 receptors (IC50>100uM) and very weakly blocks ananad amide uptake (IC50~100uM). Inhibits proliferation of C6 glioma cells. An inhibitor of fatty acid amide hydrolase (FAAH). pIC50=4.89 for inhibition of [3H]-anandamide metabolism. Displays little binding to CB1 and CB2 receptors (IC50>100uM) and very weakly blocks ananadamide uptake (IC50~100uM). Inhibits proliferation of C6 glioma cells.

Technology Process of PALMITOYLISOPROPYLAMIDE

There total 2 articles about PALMITOYLISOPROPYLAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.2%

isopropylamine (75-31-0) + n-hexadecanoyl chloride (112-67-4) → N-isopropyl-palmitoyl amide (189939-61-5)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.phytochem.2014.11.011

Reference yield:

isopropylamine (75-31-0) + 1-hexadecylcarboxylic acid (57-10-3) → N-isopropyl-palmitoyl amide (189939-61-5)

Guidance literature:

1-hexadecylcarboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In ethyl acetate; at 20 ℃; for 1h;

isopropylamine; In ethyl acetate; at 20 ℃; for 12h;

DOI:10.1016/j.bmc.2010.12.046

upstream raw materials:

isopropylamine

1-hexadecylcarboxylic acid

n-hexadecanoyl chloride

Refernces

• 1、 -. "USE OF ENDOCANNABINOID-LIKE COMPOUNDS FOR TREATING CNS DEGENERATIVE DISORDERS". Paragraph 0029-0031. . Retrieved 2017/09/12.