2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-(4-methoxy-benzyloxy)-quinoline

Base Information

Chemical Name:2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-(4-methoxy-benzyloxy)-quinoline
CAS No.:77405-71-1
Molecular Formula:C₄₁H₃₈N₂O₅
Molecular Weight:638.763
Hs Code.:

Synonyms:2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-(4-methoxy-benzyloxy)-quinoline

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Chemical Property of 2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-(4-methoxy-benzyloxy)-quinoline

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Technology Process of 2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-(4-methoxy-benzyloxy)-quinoline

There total 10 articles about 2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-(4-methoxy-benzyloxy)-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 77418-04-3
4-(4-Methoxy-benzyloxy)-2-[(E)-p-tolylimino-methyl]-phenylamine

: 77405-68-6
1-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-ethanone

: 77405-71-1
2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-(4-methoxy-benzyloxy)-quinoline

Guidance literature:: With potassium tert-butylate; In toluene; tert-butyl alcohol; for 10h; Heating;
DOI:10.1021/ja00395a071

Reference yield:

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 77405-71-1
2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-(4-methoxy-benzyloxy)-quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃, KI / dimethylformamide / 14 h / Ambient temperature

2: benzene / 14 h / Heating

3: Na₂S / methanol / 2 h / Heating

4: 96 percent / t-BuOK / toluene; 2-methyl-propan-2-ol / 10 h / Heating

With sodium sulfide; potassium tert-butylate; potassium carbonate; potassium iodide; In methanol; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; benzene;
DOI:10.1021/ja00395a071

Reference yield:

: 92541-05-4
(Z)-3-Amino-1-(2-benzyloxy-3,4-dimethoxy-phenyl)-2-methyl-but-2-en-1-one

: 77405-71-1
2-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-5,6-dimethyl-3-vinyl-pyridin-2-yl]-6-(4-methoxy-benzyloxy)-quinoline

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / xylene / 14 h / Heating

2: NaBH₄ / tetrahydrofuran; propan-2-ol / 16 h / Ambient temperature

3: 67 percent / PhPOCl₂ / 3 h / 170 °C

4: 85 percent / dimethylformamide / 14 h / Heating

5: 2.) H₂O, H⁽¹⁺⁾ / 1) C₆H₆, room temperature, 1.5 h

6: 96 percent / t-BuOK / toluene; 2-methyl-propan-2-ol / 10 h / Heating

With P,P-dichlorophenylphosphine oxide; sodium tetrahydroborate; potassium tert-butylate; water; hydrogen cation; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol; toluene; xylene; tert-butyl alcohol;
DOI:10.1021/ja00395a071